作者： admin

China’s first ＂cell knife＂ surgery for 20 years： the ＂brave＂ dance on the tip of the knife

　　He pioneered functional neurosurgery in China and was the "first person in cell knife" in China … … In the field of functional neurosurgery in China, Li Yongjie is a "myth". Under the dazzling aura, in essence, he will always be a scientist doctor who constantly explores new fields and a doctor who stands in the way of death and disease.

　　Li Yongjie is a 79-grade college student — — After the reform and opening up, the first batch of college students changed their fate through the college entrance examination. In the early 1990s, with the tide of studying abroad, he learned "one-handed" skills in traveling to the west. Although he got the green card, he resolutely gave up the choice of returning to China. In just 20 years, he created and led a discipline to rank among the international "first phalanx" … …

　　At the time of 40 years of reform and opening up, the 1.5 million-word book Functional Neurosurgery edited by Li Yongjie was published. A book, a person; A discipline, an era … …

　　Open Functional Neurosurgery, walk into xuanwu hospital Institute of Functional Neurosurgery and Beijing Institute of Functional Neurosurgery of Capital Medical University, approach Li Yongjie’s team, and learn about the development of functional neurosurgery, as if seeing the dance of "brave" on the tip of a knife, and the wonderful dance skills are the never-ending steps … …

▲ Family photo of 2018 Beijing Institute of Functional Neurosurgery. Photo courtesy of respondents

▲ Family photo of 2018 Beijing Institute of Functional Neurosurgery. Photo courtesy of respondents

　　Xinhua Daily Telegraph Press Conference Morality

　　At the fork of Zheng Xinyi’s fate, Li Yongjie, his attending doctor and director of Beijing Institute of Functional Neurosurgery, stood there with a smile — — It was he and his team who realized the dream that "China Forrest Gump" had broken one place through surgery.

　　July 12th is the 20th anniversary of the first "cell knife" operation in China. Xinhua Daily Telegraph reporter entered the organization that has become the largest number of brain pacemakers implanted in the world for 10 consecutive years — — Xuanwu hospital Institute of Functional Neurosurgery and Beijing Institute of Functional Neurosurgery of Capital Medical University.

　　He was admitted to Peking University in 1979, studied abroad in 1994, and returned to China 20 years ago to establish the Beijing Institute of Functional Neurosurgery. A few years ago, he began to explore the society to run doctors and set up outpatient departments to help more people see and be optimistic about the disease … … In the recent 40 years, Li Yongjie’s fate has been closely linked with the changes of a discipline and an era.

▲ Professor Li Yongjie.

▲ Professor Li Yongjie.

　　Open your eyes and see the world:

　　From "the first person in cell knife" to "a seed"

　　The human brain is one of the most amazing and complicated substances in the world. To move a "knife" on the brain requires not only courage, but also "real kung fu".

　　The operation that Li Yongjie cured Zheng Xinyi was called "Deep Brain Stimulation Operation". Simply put, it is to put electrodes deep in the human brain. The scientific principle is that the dyskinesia of human body is caused by pathological changes in some brain cells, and their symptoms can be controlled and regulated by electrical stimulation of the pathological cells.

▲ Professor Li Yongjie performs stereotactic surgery for patients.

▲ Professor Li Yongjie performs stereotactic surgery for patients.

　　Such an operation sounds simple, but in fact, human beings didn’t realize the relationship between human brain and consciousness and behavior until the end of the 19th century. The accurate treatment of brain tissue by surgery can be traced back to the emergence of stereotactic technology in 1947 — — At that time, the disease targeted by this technology was Parkinson’s disease, which was called "immortal cancer".

　　At first, the patient’s hands and feet showed rhythmic tremor, slow movement, difficulty in tying shoelaces and buttons, and difficulty in putting on and taking off shoes and socks. After 5 to 15 years of illness, he gradually lost his mobility … … Parkinson’s disease is a slowly progressive disease, which mainly occurs in middle-aged and elderly people. Muhammad Ali and mathematician Chen Jingrun all suffered from this disease.

　　In 1994, Li Yongjie, who had just gone abroad for postdoctoral studies, first came into contact with the cutting-edge microelectrode-guided stereotactic neurosurgery. This is a technique to stop the patient’s body tremor by destroying the "tremor cells" in the brain, which is vividly called "cell knife".

　　As a neuromodulation surgery, it uses stereotactic method to locate accurately, implants stimulation electrodes in the human brain, and controls the stimulation parameters of the electrodes in the brain through the remote control device in vitro, so as to control and improve the patient’s disease symptoms. It is the most successful case for human beings to realize the dream of "brain-computer dialogue".

　　"This kind of deep brain stimulator, also known as brain pacemaker, is the most advanced technical means for the treatment of functional encephalopathy in the international medical community since the beginning of the 21 ST century, among which the treatment of Parkinson’s disease patients is the most mature and common." Today, Li Yongjie still remembers the shock of that moment.

　　After the patient who was treated in the operating room was accurately located in the skull, a very thin electrode went deep into her brain to find the abnormal cells, and then it was "destroyed" by radio frequency heating. Within a few seconds, the violent tremor of the patient’s right hand disappeared, and her tears welled up in her eyes: "Oh, my God, it’s stopped for 10 years … …”

▲ The Institute was established in 1998-Dr. RP-Iacono, a famous functional neurosurgeon from the United States, came to congratulate him personally.

▲ The Institute was established in 1998-Dr. RP-Iacono, a famous functional neurosurgeon from the United States, came to congratulate him personally.

　　"The whole world seems to be silent, and I can only hear the voice in my heart: I must master this technology!" Li Yongjie, 57, will never forget the moment when he decided his future academic direction and even his life destiny.

　　At that time, this advanced surgical technique was still a blank in China, and doctors also called Parkinson’s disease "tremor paralysis". Li Yongjie, who has been a doctor of medicine in China for several years, knows very well that there are tens of millions of patients with nervous system functional diseases like Parkinson’s disease in China, and high-level brain surgery intervention is urgently needed.

　　After graduating as a postdoctoral fellow, Li Yongjie did not hesitate to join the world-renowned stereotactic neurosurgery — — The medical center of Linda University in Rome has mastered all the techniques of "cell knife" in only two years.

　　"There are so many patients in China, I want to go back to China and bring back the technology I have learned!" Li Yongjie’s inner voice rang again. Comfortable life, clean environment, American green card … … Nothing can stop him from returning to China.

　　"I left without hesitation." Li Yongjie said firmly.

▲ On July 12th, 1998, Li Yongjie completed the first stereotactic cell knife operation in Beijing Institute of Functional Neurosurgery.

▲ On July 12th, 1998, Li Yongjie completed the first stereotactic cell knife operation in Beijing Institute of Functional Neurosurgery.

　　On July 12th, 1998, the first "cell knife" operation in China began in xuanwu hospital. Li Yongjie, who returned from school, is a surgeon, anesthesiologist, radiologist and nurse … … Because no one knows how this "sophisticated" operation is done, he needs to personally control every link.

　　Heading, taking the patient to the nuclear magnetic room for brain scanning, positioning the surgical target, calculating the target position, craniotomy, drilling, inserting a very fine puncture needle to reach the target position, and inserting a microelectrode &hellip along the needle track; … Unconsciously, eight hours passed, and Li Yongjie, who was immersed in it, didn’t feel it at all. The doctors and nurses on the sidelines saw that the error of electrode positioning was less than 1 mm, and the patient’s trembling hand gradually stopped during the operation.

　　"The human brain is a black box. Stereotactic technology is a bit like GPS and must be accurate to the millimeter." Li Yongjie said.

　　Functional Neurosurgery Newsletter is a peer-to-peer exchange publication run by the Institute. The cover of the 10th issue published in April 2012 is a picture of Swiss national hero william tell aiming at an apple on his son’s head not far away under the oppression of colonists.

　　"Through the distant time and space, we are capturing William’s breath in the picture, pulse diagnosis’s pulse, and appreciate each other’s heart is sympathetic." Li Yongjie wrote in the article "Courage and Responsibility Create Glory" on the front page of the magazine, "Because our profession is a doctor who saves lives, and the disease is ‘ Magic ’ The doctor is a bow and arrow maker. Facing the eyes of patients seeking help or even despair, facing the challenges of difficult and complicated diseases, and facing the medical risks and sociological risks brought by treatment, we are tested and challenged every day. This not only requires our confidence in our own knowledge and skills, but also challenges our courage and responsibility. "

　　Neurosurgery, especially stereotactic surgery, is like shooting an apple with a bow.

　　"This requires a high degree of accuracy, and no mistakes are allowed, so as to ensure that patients are safe, and ‘ Shoot ’ The disease is invisible. " Li Yongjie said.

　　"It feels amazing." Lu Xiaoli, a doctor who witnessed the whole operation, remembers that after the success of the operation, more and more patients came here. By the end of 1998, Li Yongjie’s team had been able to perform dozens of "cell knife" operations every month, and a set of scientific operation standard procedures were established, and the operation time was shortened to an average of two hours.

　　"I am just a seed, bringing this technology back to China and blossoming everywhere." Li Yongjie, who is known as the "first person of cell knife", said modestly that if he has made any contribution, it is to make the stereotactic technology develop more finely and safely in China.

▲ In 1999, the National Parkinson Foundation awarded Beijing Institute of Functional Neurosurgery the title of "Clinical Center of Excellence".

▲ In 1999, the National Parkinson Foundation awarded Beijing Institute of Functional Neurosurgery the title of "Clinical Center of Excellence".

　　Parkinson’s disease is the most common type of dyskinesia. Epidemiological statistics show that there are 2 million patients in China, accounting for 40% of the total number of patients in the world. Due to the aging of the population, the incidence of Parkinson’s disease is still increasing, and it has become one of the common diseases in the nervous system of middle-aged and elderly people.

　　In 1817, the British doctor Parkinson confirmed Parkinson’s disease in his book "On Tremor Paralysis", and then the international medical community named the disease after him.

　　"This year is 201 years since Parkinson’s disease was confirmed." Li Yongjie said, "Before I went abroad, the name Parkinson’s disease had been used abroad for more than 100 years, and this disease was still called ‘ Tremor paralysis ’ . Now the country is also called Parkinson’s disease, which is the result of everyone opening their eyes to see the world. "

　　The pioneering and exploration of Beijing Institute of Functional Neurosurgery has made countless patients see hope.

　　As of July 12, 2018, in the past 20 years, Beijing Institute of Functional Neurosurgery has performed stereotactic surgery for 6,690 patients with dyskinesia, involving 13 types of functional neurosurgical diseases: Parkinson’s disease accounts for more than 3/4, followed by primary tremor (10.87%) and dystonia (7.17%), and other dyskinesia only accounts for 5.74%— — Include cerebral palsy, TIC disorder, Parkinson’s superposition syndrome, voluntary movement’s disease, chorea, etc.

　　"At the beginning of returning to China for three or five years, we were fighting alone. In the last five or six years, hospitals and universities everywhere can’t wait to develop functional neurosurgery. " Li Yongjie said.

▲2009-9-18- Professor Ali-Rezai, an American expert on dyskinesia, visited and Professor Li Yongjie signed a book.

▲2009-9-18- Professor Ali-Rezai, an American expert on dyskinesia, visited and Professor Li Yongjie signed a book.

　　The brave are invincible:

　　Let functional neurosurgery blossom in China in 20 years.

　　Starting from the first "cell knife" operation 20 years ago, China has established a multi-level and all-round discipline framework of functional neurosurgery, which focuses on dyskinesia, epilepsy surgery and pain, and spreads to neuromuscular spasm and psychosurgery.

　　Li Yongjie’s "battlefield for one person" has also become a "team competition".

　　At that time, xuanwu hospital established the Beijing Institute of Functional Neurosurgery because of his return, which is the first clinical treatment and scientific research institution in the field of functional neurosurgery in China. Since 2009, it has become the world’s largest "Deep Brain Stimulation Treatment Center", and the number of brain pacemakers implanted has been the first in the world for 10 consecutive years.

　　"This is the result of a team competition, but the high technology of the brain stimulator comes from the other side of the ocean. No matter how big the implant is, it just follows, not leads." Li Yongjie is very sober. "It’s my real mission to return to China to start a business, not to be a flash in the pan, but to develop steadily."

　　Faced with the huge medical demand and the blank field of functional neurosurgery in China at that time, the doctor with elegant appearance and slow speech showed the well-known word "courage" and shouldered the two burdens of talent training and discipline construction.

　　It is hard to imagine that when Li Yongjie cured Zheng Xinyi’s "spastic cerebral palsy" in 2010, brain electrode implantation was still in the early clinical exploration in the world. This means that his frontier exploration will inevitably have the risk of failure.

　　Li Yongjie admits that although he "cherishes feathers", he wants to be a good brain surgeon, "focusing on intelligence in the short term, ability in the medium term and responsibility in the long term". To this end, he set a rule for surgery: "I will do the most difficult, latest and risky surgery!"

▲ Professor Li Yongjie performs endoscopic surgery.

▲ Professor Li Yongjie performs endoscopic surgery.

　　Once, Li Yongjie met an epileptic with a particularly complicated condition. After she failed in an operation in a foreign country, she was introduced to see a doctor by a medical elder. But after an impeccable craniotomy, her condition actually relapsed. This means that the previous judgment of the lesion is likely to be wrong.

　　When Li Yongjie was called to the ward by his colleagues, what he saw was such a scene: the patient’s mother was sitting on the windowsill, desperate. Based on careful observation, Li Yongjie made a decisive second craniotomy and confirmed that the real lesion was in the parietal lobe of the brain, less than 2 cm away from the motor cortex of the brain.

　　Do you want to do the third craniotomy? Who will do it? Li Yongjie did not hesitate to stand before the operating table. He carefully removed the focus cells as big as the fingernail, avoiding the dangerous motor cortex injury.

　　"The patient is only 16 years old. If he is paralyzed by surgery, the young doctor may not be able to bear this huge psychological burden, then I will come." He smiled and recalled as if those thrilling "moments of life and death" were as usual.

　　Dr. Lu Xiaoli, who has been following him, commented that he was "not angry and arrogant" — — "When he is around, everyone relies on him from the heart, which is the personality charm of Professor Li".

　　He is honest with others.

　　"If you don’t look at it, as long as I pick it up, I must be responsible for the patient to the end." Li Yongjie said, "It must be that those who dare to take responsibility make rapid progress, and those who are afraid of accidents make slow progress. In the end, it is better than taking responsibility."

　　"Teacher Li often tells us that being a good doctor is the first priority. For diseases that can be cured, the treatment should be serious and accurate, and the best treatment plan should be discussed for difficult cases. For diseases that have no treatment for the time being, patients and their families should correctly understand and face the disease positively. ‘ Sometimes it’s healing, often it’s helping, always comforting ’ 。” Zhou Changshuai, a student in Li Yongjie, once quoted this sentence to describe his mentor in an article entitled "The Short Story of big doctor".

　　More than 100,000 patients from all over the world were diagnosed and treated, and more than 10,000 cases were treated by surgery … … After 20 years, Li Yongjie has realized his ambition of returning to China: 16 "Xuanwu workshops" for hospitals across the country have trained a high-level "national team" of functional neurosurgery and trained thousands of doctors across the country; Cutting-edge technologies such as "cell knife", deep brain stimulation and endoscopic surgery have been introduced into China, and the number of diseases that can be diagnosed and treated has expanded to more than 30.

　　"I am obsessive-compulsive disorder and perfectionist." Li Yongjie said, "Scientific research is a kind of spirit, attitude and method. To treat scientific research as work and work as scientific research, we must understand and clarify, run the spirit of scientific research through our work, and constantly expand the scope of application of technology."

　　Someone asked Li Yongjie, "Aren’t you afraid to teach your disciples and starve your master?" He laughed: "I have so many new technologies and fields to learn, how can I have time to think about them?"

▲ Professor Li Yongjie is doing popular science propaganda in the column "The Road to Health".

▲ Professor Li Yongjie is doing popular science propaganda in the column "The Road to Health".

　　Parkinson’s disease, primary disorder, dystonia, TIC disorder, voluntary movement’s disease, cerebral palsy, myotonia and other motor disorders, various epilepsy diseases, chronic pain such as central pain, peripheral nerve injury pain, cancer pain, visceral pain, soft tissue pain, low back pain, neck and shoulder pain, and neurospinal diseases such as lumbar disc herniation and cervical disc herniation & HELIP; … Experts from Beijing Institute of Functional Neurosurgery have treated or operated on more than 30 diseases recorded in Functional Neurosurgery.

　　"In the field of functional neurosurgery, a comprehensive platform for treating diseases like ours can’t be found all over the world." Li Yongjie’s tone is gentle, but he is confident and proud. "In 20 years, I set up a platform for discipline development and brought out a team. Even if I retire, this subject will continue to develop. "

　　In the conference room of the Institute of Functional Neurology, picture frames are hung on the wall in order, and each one is longer than the other — — Because this is the annual photo of the Institute.

　　"Under the leadership of Director Li, our group photo lasted for 20 years. We are a big family and the team is getting bigger and bigger, so the group photos are getting longer and longer. " Lu Xiaoli said.

　　Looking back on the 40 years of reform and opening-up, Li Yongjie was filled with emotion: "We have caught up with the era of reform and opening-up, which is the best and fastest period of economic, social, knowledge, science and technology development in China for thousands of years. From an ignorant teenager to a medical expert and academic leader, from an entrepreneur with dreams to the ideal landing and rooting, my growth and harvest are all thanks to the times. "

　　"From an idiotic dream to a dream come true, I am more like the child running on the beautiful beach. Among the sea goods surrounded by waves on the beach, I am delighted to find several colorful shells … … Looking around, there are so many such children! "

　　Ten years ago, Li Yongjie wrote this passage with emotion, which is meaningful today.

▲ In 2015, Professor Li Yongjie won the title of "Top Ten Health Guards in the Capital".

▲ In 2015, Professor Li Yongjie won the title of "Top Ten Health Guards in the Capital".

　　Always on the road:

　　A restless scientist

　　Sharpen a sword in 20 years.

　　The team of more than 100 people led by Li Yongjie has become the world-famous "China Team" in the field of functional neurosurgery, and ranks among the international "first phalanx" — — Beijing Institute of Functional Neurosurgery was awarded the title of "Clinical Center of Excellence" by international institutions as early as 1999, becoming the only clinical institution in Asia to receive this honor.

　　What else does he want?

　　"I am a restless person, and I naturally like to do something new and different." There was a childlike look on his face. "I hope to be recognized as a scientist doctor."

　　In fact, it was Li Yongjie’s childhood dream to be a scientist, but it was accidental to study medicine.

　　In 1960s, he was born in an ordinary family in Datong City, Shanxi Province. In that special time when "sports followed sports", Li Yongjie was a "silent, timid" child because of his family background of "rich peasants", and he was "aged and lonely out of proportion to his age".

　　But under his seemingly "juvenile maturity" appearance, there is an interesting and curious soul hidden. He loved natural science since he was a child, and when he was 6 years old, he had a whim to make a perpetual motion machine with water currents and waterwheels. After the Tangshan earthquake, he hung a small hammer with enameled wire and passed through the ring. As long as it shook, it would trigger the ringing of the electric bell. He was very proud of this homemade "seismograph". At the age of 15, he climbed onto the roof to install an antenna, and the self-made "crystal receiver" actually received china national radio’s voice … …

　　In 1977, China resumed the national college entrance examination and entered the "scientific spring" with emphasis on education and knowledge.

　　"The resumption of the college entrance examination has restored the vitality of the social class." In 1979, Li Yongjie, who won the first prize in Shanxi Physics Competition, gave up the opportunity to attend the university of Shanxi Province without taking the exam and chose to take the college entrance examination, and was admitted to the top 20 in the province. His mother said, "If only our family could have a doctor, you could study medicine", which made him filial and medicine accompany him ever since.

　　In 1991, Li Yongjie, who received a doctor’s degree in medicine from Shanxi Medical University and published two English papers in Brain Research magazine, saw the huge gap between domestic and foreign advanced technology. A strong thirst for knowledge made him "desperate" and sold his newly allocated house to study abroad.

　　"My growth and harvest are all thanks to the times. If I don’t catch up with the golden age of 40 years of reform and opening up, I may not be able to dominate my own destiny." He said, "Therefore, I firmly believe that my seed will be the home only if it falls on the land of the motherland, and it will grow most vigorously."

　　"The door of opportunity opened by reform is getting bigger and bigger, and the chances that individuals can dominate their own destiny are getting higher and higher." Li Yongjie, which chose to return to China, has indeed achieved "the most vigorous growth" — — Under his leadership, Beijing Institute of Functional Neurosurgery keeps track of the latest development of functional encephalopathy in the world, improves technical methods, improves the level of treatment and expands the scope of treatment.

▲ In 1999, Professor Li Yongjie communicated with the Swedish doctor LV-Laitinen, a pioneer of functional neurosurgery.

▲ In 1999, Professor Li Yongjie communicated with the Swedish doctor LV-Laitinen, a pioneer of functional neurosurgery.

　　In March 1999, the Institute of Functional Neurosurgery successfully treated Parkinson’s disease with subthalamic nucleus destruction technology, and in the same year, deep brain stimulation technology (brain pacemaker therapy) was developed to treat Parkinson’s disease.

　　In May, 1999, the first operation to treat generalized torsion spasm was successful.

　　In the second half of 1999, the first operation to treat spastic torticollis, chorea and Tourette’s syndrome was successful one after another.

　　In the new century, after creatively expanding the scope of surgical treatment to other dyskinesia diseases, his team began to pay attention to the work in the field of surgical treatment of epilepsy and pain … …

　　"Yongjie’s team has always led the development of functional neurosurgery in China, from treating Parkinson’s disease to epilepsy to pain … …” Professor Yuxi Liu of Shanxi Medical University said.

　　In the past three years, the average annual operation volume of Beijing Institute of Functional Surgery was over 1,600, and a team with their own strengths and vitality also grew up — —

　　Zhang Guojun and Yu Tao focus on the localization of epileptogenic focus and microsurgical treatment of intractable epilepsy; Hu Yongsheng specializes in surgical treatment and nerve regulation of chronic pain; Zhu Hongwei is good at neurospinal and cranial neuropathy; Li Jianyu has 20 years of experience in surgical treatment of dyskinesia … …

▲ Professor Li Yongjie gave a keynote speech at the 2017 Chinese Conference on Functional Neurosurgery.

▲ Professor Li Yongjie gave a keynote speech at the 2017 Chinese Conference on Functional Neurosurgery.

　　In September 2017, the Huaxia Conference on Functional Neurosurgery was held in Beijing, and more than 20 top scholars in the world and more than 100 well-known experts in China arrived as scheduled.

　　In his speech at the conference, Li Yongjie introduced the summary of the world’s largest surgical cases of dyskinesia completed by the Institute in the past 20 years: a total of 6,467 cases were treated by surgery, and it was also found that the risk of Parkinson’s disease in men was 1.46 times that of women, and the overall dyskinesia was 1.45 times; At the age of onset, half of the patients with Parkinson’s disease developed before the age of 53, and half of them received surgery before the age of 61.

　　In the first 10 years after returning to China, Li Yongjie devoted himself to improving the diagnosis and treatment of Parkinson’s disease and epilepsy to the international level, and then he turned his attention to the treatment of chronic pain.

　　"The most common and harmful pain is disc herniation. My focus now is how to make it more meticulous and minimally invasive, in line with international concepts and models." He said.

　　Exploration is always on the road — —

　　"Science, solve ‘ Day ’ The problem; Technology, solve ‘ Land ’ The problem. I am still optimistic about the prospect of surgical treatment of emotional disorders such as major depression, hoping to find that key and open the door to the connection between heaven and earth. " He said.

▲ Professor Li Yongjie spoke at the 10th anniversary celebration of Beijing Institute of Functional Neurosurgery.

▲ Professor Li Yongjie spoke at the 10th anniversary celebration of Beijing Institute of Functional Neurosurgery.

　　Li Yongjie, a member of the Standing Committee of the Beijing Municipal Political Consultative Conference, has repeatedly encouraged and called for the reform of the medical system. He has also done his best: in 2014, he promoted social capital to set up the Beijing Xidian Clinic, so that the advanced national specialized medical model can take root and explore a new path of graded diagnosis and treatment.

　　"Medical reform has entered the deep water area, which requires not only the skills of those who bow and arrow ‘ Emboldened ’ It requires the sense of responsibility of those involved in medical reform and the courage and responsibility of reformers. The reform of the medical system is risky, and it is even more risky if the medical system is not reformed. Go on the road with responsibility, courage and responsibility, because we believe that after twists and turns and even dangers, we will eventually reap glory. " Li Yongjie’s words spoke out the common aspiration of the participants in the western clinic.

　　"Every discipline has its scientific, systematic and complete requirements and development expectations … … As far as I am concerned, more than 20 years of study, research, practice and teaching experience in the field of functional neurosurgery are even more eager for it. " In 2018, Li Yongjie led the team to compile the lifelong learning and practice into a 1.5-million-word masterpiece Functional Neurosurgery. "The editorial team adheres to the concept of combining theoretical interpretation with clinical practice, and hopes to weave a whole picture in the field of functional neurosurgery with this context, hoping that it will become a classic in the field of functional neurosurgery."

　　"Patients with functional diseases of the nervous system account for more than 10% of the total population, and there are tens of millions of people who need interventional therapy. The number of people who can benefit from surgery is conservatively estimated to be as high as 5 million, which is about 10 times that of patients with brain tumors. Such a huge demand for medical services cannot be ignored, and historic opportunities for discipline development should not be missed. " He appealed in the preface.

　　In October 2017, Zhu Hongwei and Zhang Jiaxing of Beijing Institute of Functional Neurosurgery participated in an important international academic conference in neurosurgery, and found that this conference "no matter the lecture content or the frontier field display, the function and nerve spine account for nearly half, and everyone is working hard on stereotactic, navigation and artificial intelligence … …”

　　"This conference really shows the future development direction of neurosurgery, from which we can see our shortcomings and our status. It is proud that many of the work of the Beijing Institute of Functional Neurosurgery is at the forefront of the world. I believe that in new fields, we will also keep up with the international pace and make our own characteristics in the field of neurospinal surgery. " Zhang Jiaxing said.

▲ Playing basketball is Li Yongjie's favorite sport.

▲ Playing basketball is Li Yongjie’s favorite sport.

　　In the face of achievements, Li Yongjie was unusually sober.

　　"We let the international advanced technology take root and bear fruit in China, and even ran away with international counterparts in clinic. Of course, there is innovation in this, but deep brain stimulation technology was invented abroad, and we still lack real original inventions. We need to open up new fields and invent new equipment, and start with creativity, research and development, market development and resource integration to establish a complete chain of scientific research and industrial development. " Li Yongjie said, "From quantitative change to qualitative change, this possibility has greatly increased now."

　　Li Yongjie revealed that his team is brewing non-invasive surgery. "This is the next step in surgery and treatment, and it will be a big breakthrough. I am optimistic about it."

　　On the occasion of Functional Neurosurgery in Fu Zi, it was the time when Alpha Go defeated the top human Weiqi players.

　　"The brain has 60 billion to 70 billion brain cells. If you regard them as planets, then the brain is as infinite as the universe." Li Yongjie, who is optimistic about brain-computer interface, said excitedly that if we can join hands with engineers, it may connect human imagination and mobility. "That will open up a new world of functional neurosurgery".

Cheng Er： The car model goddess with high temperament and emotional intelligence, Tik Tok Aauto Quicker grabs your heart instantly.

In Tik Tok and Kuaishou, a name frequently appears in everyone’s sight, and that is Cheng Er. This goddess with high temperament and emotional intelligence, with her excellent car model image and unique personal charm, quickly accumulated more than 500,000 fans in Tik Tok and 1.9 million fans in Aauto Quicker, and became an internet celebrity. Cheng Er is not only a car model, but also a perfect movie, which makes people involuntarily want to follow her path.

Every time she appears in front of the camera, it seems that a visual feast begins. Every appearance of her is an interpretation of beauty and a love for life. From meticulous makeup to flawless figure, Cheng Er can always show an enviable temperament in front of the camera, perfectly leading the new trend of the car model industry. With the rise of video platform, more and more people appreciate her style. In her way, Cheng Er shows us that car models are not only a simple display, but also an art..

Cheng Er’s success is not only due to her beautiful appearance, but also to her profound emotional intelligence. She always shows friendliness and sincerity in the interaction with fans, which makes her not only have followers in data, but also gain a group of loyal fans. Whenever she shares her life tips or interacts with fans in the live broadcast, the audience can always feel the warmth from the bottom of my heart. Cheng’s sense of humor and affinity make her stand out in the car model industry and become an example for many young women.

Not only that, Cheng Er’s works are also full of movie-like feelings. Whether it is every video of her or every appearance at the auto show, it gives people a visual enjoyment. Cheng Er is good at using all kinds of shooting techniques and skillfully shows the combination between himself and the car to the fullest. Her elegant posture complements the streamlined design of the car and seems to tell the story behind every car for the audience.

In the current trend of content creation, Cheng Er’s success illustrates an important trend: the audience is not only eager to see wonderful visual pictures, but also hopes to feel the emotional communication through the people behind these pictures. Modern network celebrities are no longer just isolated "performers", but life sharers who can resonate with their audiences. This is one of the reasons why Cheng Er can quickly accumulate a large number of fans in a short time.

Recently, a video released by Cheng Er on social media has aroused widespread concern. In the video, she not only showed the latest luxury cars, but also shared her feelings about life and her vision for the future. There is wisdom and firmness in her words, as if every word is a kind of resonance, which makes people want to stop and listen carefully. This is also the charm of Cheng Er-under the glamorous appearance, there is a convincing truth and strength.

Not only that, Cheng Er’s performance in the car model industry also shows many people another possibility for women in the workplace. Her job needs not only physical attractiveness, but also strong inner and self-confidence. This industry is full of competition, and Cheng Er uses his own efforts and persistence to tell everyone that even in such a fierce environment, he can still do his best.

Finally, Cheng Er is not only a online celebrity on social network, but also a representative of life attitude. Through her, we see a hope: while pursuing beauty, we should also pursue inner abundance. The perfect combination of temperament and emotional intelligence makes her a "goddess" in the hearts of many young girls. Whether in the life before or after the camera, Cheng Er is constantly challenging himself, breaking through himself and inspiring more people to pursue their dreams. In the future, we expect Cheng Er to bring us more surprises and touches, and continue to use her stories and experiences to touch more people’s hearts.

Bacteria in the mouth are quietly ＂detonating＂ these eight diseases.

Original rehabilitation magazine

There are hundreds of millions of microorganisms living in our mouth, with nearly 800 species, which together constitute the oral microflora. Like the intestinal flora, the oral microflora is also very diverse. Most of them are resident bacteria that coexist with human beings for a long time. They are generally harmless and even beneficial to human bodies, and they are "good friends" of our bodies. Under normal circumstances, the resident microorganisms in the oral cavity form a stable ecological balance, and once the ecological balance is broken, "good friends" will also become "bad molecules", which will spread to other parts of the body through blood, digestion and breathing, causing or aggravating various serious diseases.

The first type: cardiovascular and cerebrovascular diseases.

The oral cavity is connected with the outside world, which is the gateway for all kinds of microorganisms to enter the body. Streptococcus mutans in oral cavity and Porphyromonas gingivalis are the "culprits" of dental caries and periodontal disease respectively. Periodontal disease not only leads to tooth loosening and falling off, but also is closely related to life-threatening cardiovascular and cerebrovascular diseases such as stroke and myocardial infarction. Scientists have detected common microorganisms in the oral cavity in atherosclerotic plaques of such patients, among which Porphyromonas gingivalis has the largest number, and the more serious periodontal disease is, the larger the plaque area is.

Periodontal bacteria and their harmful metabolites can enter the blood through the broken gums, causing damage to blood vessels, aggravating atherosclerosis and further increasing the risk of stroke and myocardial infarction. Studies have confirmed that the symptoms of cardiovascular and cerebrovascular diseases have also been alleviated after periodontal treatment.

The second type: diabetes

There is a strong two-way relationship between type 2 diabetes and periodontal disease. The increase of inflammatory factors in patients with severe periodontitis interferes with the role of insulin as a "porter" of blood sugar, leading to excess sugar in the blood and causing blood sugar fluctuation, so the risk of developing diabetes in patients with periodontitis is 2~3 times that of normal people.

However, diabetic patients often have dry mouth, and their oral self-cleaning ability decreases, making it easier for germs to breed and multiply; At the same time, the resistance and healing power of gums are weak, and the rising blood sugar will provide more "nutrients" for oral bacteria, which will lead to more serious inflammation. This interaction has formed a vicious circle. Studies have pointed out that perfect periodontal treatment can reduce glycosylated hemoglobin and fasting blood glucose and improve patients’ systemic symptoms.

The third kind: autoimmune diseases.

Autoimmune diseases are a kind of diseases that attack human tissues or organs due to abnormal immune system. They are all serious chronic diseases. Inflammation is the common feature of these diseases, and infection caused by oral pathogenic microorganisms is one of the important causes of autoimmune diseases. For example, Porphyromonas gingivalis is related to the occurrence and development of rheumatoid arthritis, inflammatory bowel disease and systemic lupus erythematosus. Candida albicans is closely related to Sjogren’s syndrome.

Imagine that if the "bad molecules" in the mouth are very active, the immune system will always be in a state of "high alert", and inflammation in the body will persist, which will lead to systemic symptoms in the long run. If you have a related disease, but the condition is not controlled as expected, you may have to pay attention to whether the flora in your mouth is disordered.

The fourth kind: digestive system diseases.

The oral cavity is the initial part of the digestive tract, and Helicobacter pylori (Hp) in the oral cavity is also related to the occurrence of gastrointestinal diseases. Oral cavity may become the repository of Hp, increasing the risk of infection, and then causing gastritis, gastric ulcer and other diseases; Hp was also found to be related to Hashimoto’s thyroiditis.

Fifth: Alzheimer’s disease.

Alzheimer’s disease, commonly known as "Alzheimer’s disease". With the decline of immunity, the decrease of saliva and the need to wear dentures in the elderly, the oral microecology is prone to disorder, which is characterized by the increase of periodontal bacteria and the higher number of fungi than young people.

Periodontal pathogens and their toxic products can invade the brain through blood circulation and neural pathways, colonize in the brain, release toxic substances to cause neuronal apoptosis, and accelerate the progress of Alzheimer’s disease; Fungal infection can not only cause oral mucosal lesions, but also destroy the blood-brain barrier of the elderly and damage the central nervous system. In addition, herpes simplex virus and cytomegalovirus, which are common in oral cavity, have also been found to be related to cognitive and memory disorders.

Sixth: respiratory diseases

As the front entrance of respiratory tract, the microbial status of oral cavity directly affects the health of respiratory system. Bacteria and secretions in the mouth may be inhaled into the respiratory tract, blocking the smaller bronchi and increasing the risk of pneumonia and bronchitis, especially for the elderly and immunocompromised people. Studies have shown that people with poor oral hygiene are about 30% more likely to suffer from chronic obstructive pulmonary disease (COPD) than those with healthy oral hygiene.

Seventh: pregnancy complications

Oral health has an important impact on pregnancy and newborn health. During pregnancy, due to the rapid changes in hormone levels, pregnant women’s gums are more prone to swelling and inflammation, and 60%~70% of pregnant women worldwide suffer from pregnancy gingivitis. Poor oral health may also increase the risk of complications such as gestational diabetes mellitus and preeclampsia.

At the same time, pregnant women with severe periodontitis, their periodontal pathogens can break through the gums and directly act on the placenta and uterine cavity with blood, stimulating uterine contraction, resulting in premature delivery and low birth weight, which is 7.5 times higher than that of healthy pregnant women, which is greater than the impact of smoking and drinking on the fetus.

Eighth: cancer

Oral microorganisms are closely related to the occurrence and development of various tumors. At present, it is known that the imbalance of oral flora, candida albicans, human papillomavirus infection and other factors will promote the course of oral squamous cell carcinoma, and many typical oral "bad molecules" will become "accomplices" of cancer, especially digestive system tumors, such as Fossetta and Porphyromonas gingivalis, which are related to esophageal cancer. Fusobacterium nucleatum can enhance the viability of cancer cells and can grow in colorectal cancer. If it exists, the survival rate and prognosis of colorectal cancer patients are poor.

Link: Tips for maintaining oral health

Oral cavity is the starting point and gateway of human defense, and it is very important to maintain the ecological balance of oral microflora. Only with a good mouth can you be healthy. Let the "good friends" in the mouth guard the first line of defense of health for us.

1. Use a soft-bristled toothbrush, brush your teeth at least twice a day for 3 minutes each time, and use dental floss and a tooth washer to clean every tooth surface and gap. It is more important to brush your teeth before going to bed at night. Patients with removable dentures, fixed dentures and dental implants need to be cleaned more carefully because dentures are easy to hide evil people and shelter evil people.

2. Pap brushing method is used for permanent teeth, and circular arc method can be used for deciduous teeth. On the basis of children’s insistence on brushing their teeth, parents should also help and supervise their children to brush their teeth.

3. Eat more foods rich in protein, minerals and vitamins, eat less high-sugar foods and rinse your mouth after eating. The mouthwash containing bactericide will lead to microbial imbalance, so it needs to be used according to the doctor’s advice.

4. Avoid smoking and drinking, use less antibiotics, develop good habits of work and rest and defecation, and stay up late less to prevent disturbing the flora.

5. Conduct oral examination once every six months to find and actively treat oral diseases as soon as possible; Wash your teeth regularly and give them a thorough cleaning.

Wen | Xiang Meijuan Attending Physician of Stomatology, Shanghai Hospital of Traditional Chinese Medicine

Guiding Expert | Xuan Jing, Chief Physician of Stomatology, Shanghai Hospital of Traditional Chinese Medicine

Editor | Wang Jingming

Figure | pexels

Audit | Ye Haixia

Producer | Li Wenjing

Medical Support | Shanghai Medical Association Science Popularization Branch

Original title: "Bacteria in the mouth are quietly" detonating "these 8 diseases"

Read the original text

Baoding Pentium pony price reduction information, the lowest price is 19,900! Not to be missed

Welcome to car home Baoding Special Promotion Channel, which brings you an exciting news today. We have learned that the high-profileBenteng ponyThe model is carrying out an unprecedented preferential activity in this area. The highest discount rate reached an astonishing 0.5 million yuan, which brought tangible car purchase benefits to consumers. The starting price has been adjusted to an attractive 19,900 yuan. This is an opportunity not to be missed to buy a car. If you are interested in Pentium Pony, please click the "Check Car Price" button in the quotation form to get a higher level of discount!

保定奔腾小马降价信息，最低售价1.99万！不容错过

The exterior design of Pentium Pony is full of dynamic and vitality. The front face adopts a family-style sharp design, and the air intake grille is exquisite and recognizable. With the streamlined body lines, the overall style presents a perfect fusion of fashion and sports. Its unique body shape not only shows a sense of strength, but also reveals the pursuit of future technology, which makes people unforgettable.

保定奔腾小马降价信息，最低售价1.99万！不容错过

Pentium pony shows its unique side charm with its exquisite body proportion. It has a body length of 3000mm, a width of 1510mm and a height of 1630mm, creating a stable body posture. The wheelbase is as long as 1953mm, which makes the front and rear wheel tracks 1290mm, ensuring excellent handling and stability. In tyre size, it uses 145/70 R12 tires, and the front and rear wheels are consistent. With exquisite rim design, it not only enhances the visual effect, but also ensures the comfort and grip during driving. On the whole, the side design of Pentium pony is not only practical, but also reveals a strong sports atmosphere.

保定奔腾小马降价信息，最低售价1.99万！不容错过

The interior design of Pentium pony is simple and practical, paying attention to details. The steering wheel is made of plastic material with good texture, which is comfortable to hold and incorporates humanized design elements. The center console is equipped with an intuitive and easy-to-operate multimedia system, and the USB/Type-C interface is located in the front row, which is convenient for drivers and passengers to charge or connect devices at any time. The seat is made of fabric, which is soft and durable, and provides the functions of front and back adjustment to meet the individual needs of passengers. The rear seats support the proportional tilting, which further enhances the space flexibility and provides convenience for daily travel and loading. The overall interior design gives consideration to comfort and functionality, creating a warm interior environment for drivers and passengers.

Pentium pony is equipped with an engine with relatively stable power performance, with a maximum power of 20 kW and a torque output of 85 Nm. Although the parameters are relatively basic, they are enough to meet the daily driving needs, providing stable power output and good fuel economy.

Generally speaking, car home car owners expressed their unique and appreciative attitude towards the exterior design of Pentium pony. He emphasized the personalized appearance elements of the vehicle, especially the headlights on both sides and the shape of the rear window, which added unique charm to the Pentium pony. Although the appearance may not satisfy everyone’s aesthetics, Pentium pony is undoubtedly a successful attempt for those car owners who seek individuality and recognition. This evaluation undoubtedly provides a reference for those consumers who have a sense of design, making Pentium pony more attractive in the market.

Steady progress! ＂Four Highlights＂ Eye-catching China’s economy opens a new game in the first quarter.

CCTV News:The State Council Press Office held a press conference on the morning of April 16th, and the relevant person in charge of the National Bureau of Statistics released the main data of national economic operation in the first quarter. From the perspective of various core indicators, China’s economy continued to pick up and made a good start.

According to preliminary accounting, in the first quarter of 2024, the GDP was 296.299 billion yuan, with a year-on-year increase of 5.3% at constant prices. In terms of industries, the added value of the primary industry was 1,153.8 billion yuan, a year-on-year increase of 3.3%; The added value of the secondary industry was 10,984.6 billion yuan, an increase of 6.0%; The added value of the tertiary industry was 17,491.5 billion yuan, an increase of 5.0%.

In the first quarter, industrial production grew rapidly. The added value of industrial enterprises above designated size increased by 6.1% year-on-year, and that of high-tech manufacturing increased by 7.5%, 2.6 percentage points faster than that in the fourth quarter of last year. 1— In February, the total profits of industrial enterprises above designated size reached 914.1 billion yuan, up 10.2% year-on-year.

In the first quarter, market sales grew steadily and service consumption grew rapidly. The total retail sales of social consumer goods was 12,032.7 billion yuan, a year-on-year increase of 4.7%. Retail sales of services increased by 10.0% year-on-year.

The total import and export volume of goods was 10,169.3 billion yuan, up 5.0% year-on-year, and the trade structure continued to be optimized. Investment in fixed assets in China increased by 4.5% year-on-year, 1.5 percentage points faster than that in the previous year, and investment in high-tech industries increased rapidly.

In the first quarter, the national consumer price was flat year-on-year, and the employment situation was generally stable. The income of residents has increased steadily, and the income of rural residents has increased faster than that of urban residents.

Sheng Laiyun, deputy director of the National Bureau of Statistics, said that on the whole, the national economy started well in the first quarter, and the positive factors accumulated, which laid a good foundation for achieving the goals and tasks for the whole year.

The contribution rate of consumption to economic growth reached 73.7% in the first quarter.

In the economic data of the first quarter, we also selected several highlights:Strong consumption vitality, overall stable prices, continuous cultivation of new quality productivity, and industrial recovery.. First of all, in terms of consumption, in the first quarter, the contribution rate of consumption to economic growth reached 73.7%, which played an important supporting role in the economic recovery.

In the first quarter, physical consumption was generally stable. The total retail sales of social consumer goods increased by 4.7% year-on-year in the first quarter, and the total retail sales of social consumer goods exceeded 12 trillion yuan.

At the same time, service consumption grew rapidly. In the first quarter, the retail sales of services increased by 10% year-on-year, which was 6 percentage points higher than the retail sales of commodities. Residents’ service consumption expenditure accounted for 43.3%, an increase of 1.6 percentage points over the same period last year. Service consumption is accelerating.

In addition, online consumption continues to be strong. In the first quarter, the online retail sales of physical goods increased by 11.6% year-on-year. Driven by some new technologies, the new online sales model was constantly innovated and the sales record was constantly refreshed.

Since the beginning of this year, the upgrading consumption of Chinese residents has continued to improve. From the retail point of view, the year-on-year growth rate of sales of sports and entertainment products and communication equipment exceeded double digits. From the perspective of residents, the expenditure on transportation and communication, education, culture and entertainment are also double-digit growth.

In the first quarter, the consumer price index was generally stable.

Consumption is full of vitality. At the same time, the consumer price index (CPI) is generally stable. Official website, the National Bureau of Statistics, released a trend chart on the rise and fall of consumer prices in China, with the blue chart showing year-on-year and the yellow chart showing month-on-month. It can be seen that in March 2024, the national consumer price rose by 0.1% year-on-year and decreased by 1.0% quarter-on-quarter. At the press conference, Sheng Laiyun, deputy director of the National Bureau of Statistics, analyzed that the data in March was mainly due to the seasonal decline in prices after the Spring Festival, and the prices of services such as food and tourism dropped significantly. From a quarterly perspective, the consumer price index is generally stable.

Sheng Laiyun said that from the CPI index itself, the CPI was negative in the fourth quarter of last year, and the average CPI in the fourth quarter was -0.3%, while the CPI in the first quarter of this year was flat year-on-year. From the perspective of ring comparison, the ring comparison in the first quarter of this year was 0.3 percentage points higher than that in the fourth quarter of last year, which is consistent with the economic recovery.

Sheng Laiyun said that from the future trend, consumer prices will slowly pick up at a low level. On the one hand, the economy continues to improve and the total demand is picking up, which is a very important fundamental factor to support the CPI recovery. In addition, the prices of some agricultural products have also reached the inflection point of price adjustment, such as the price of live pigs. The next holiday consumption, including "May Day", will continue to drive the tourism-related travel consumer prices to pick up.

New quality productivity is constantly being cultivated and developed.

Judging from the relevant data in the first quarter, the development of new quality productivity has also begun to show new results in some industries and products.

From the perspective of new industries, emerging industries continue to accelerate their development. In the first quarter, the added value of high-tech manufacturing above designated size increased by 7.5% year-on-year, up by 2.6 percentage points over the fourth quarter of last year; The high-tech service industry continued to maintain a rapid growth trend, with the added value of information transmission, software and information technology services increasing by 13.7%, 2.5 percentage points higher than that in the fourth quarter of last year.

New investment and new infrastructure continued to show a good momentum of development. In the first quarter, investment in high-tech industries increased by 11.4% year-on-year, 1.1 percentage points higher than last year; Investment in high-tech service industry increased by 12.7%.

The upward trend of industrial economy will continue.

Sheng Laiyun, deputy director of the National Bureau of Statistics, introduced at the press conference that under the influence of various factors, the industrial recovery was good in the first quarter, and from the perspective of the development of the post-trend, the industrial economy will continue to recover. However, he also said that China is still in the stage of structural adjustment, transformation and upgrading, and some enterprises have to carry out transformation and upgrading, so they have to bear some pains of transformation.

Sheng Laiyun introduced that the industry recovered well in the first quarter, first of all, it was promoted by policies, and the confidence of enterprise development was increasing.

At the same time, there were positive changes in both internal and external demand in the first quarter. Exports in the first quarter were better than expected, and the industrial product export delivery value was 0.8% in the first quarter of this year, up 3 percentage points from the fourth quarter of last year. From the perspective of domestic demand, the added value of consumer goods in the first quarter of this year increased by 4.2% year-on-year, rising by more than 4 percentage points.

In addition, the industrial recovery is also related to the promotion of some recent policies.

Sheng Laiyun introduced that the central government has introduced a large-scale policy of upgrading equipment and replacing consumer goods with old ones, which has also enhanced the confidence of enterprises to a certain extent. Some enterprises can arrange production in advance. There is also a good reason for the rebound, which is related to the continuous cultivation of new kinetic energy.

Sheng Laiyun said that from the perspective of the post-trend, several reasons that support the industrial recovery will continue to play a role in the future, so comprehensive judgment shows that the industrial economy will continue to recover.

Sheng Laiyun said at the press conference: "In the next stage, China is still in a critical stage of structural adjustment, transformation and upgrading, and some enterprises have to carry out transformation and upgrading, so everyone has to bear some pains of transformation. Due to the adjustment of traditional industries and the cultivation of new kinetic energy, it is normal for some economic growth fluctuations to occur, but the quality of development is constantly improving and high-quality development is constantly improving. This is the fundamentals of China’s economic recovery. "

Sogou Xiao P： Building the most geek office style.

Focusing on the office applications made by several major Internet companies in China, you will find that RTX has done chatting, organizational structure has solved the communication problem, and on this basis, it has also done approval and attendance, and Baidu Hi has done news and Baidu space. In fact, chatting, approval and community are the three most frequently needed things.

Service number can realize information transmission well. Small P team invites all departments and functional teams to open service numbers on small P, so that all sogou people can pay attention to them publicly. In the past, HR and IT departments needed to spend a lot of time explaining how to apply for a residence permit and set up a VPN. Now, everyone can brush the raiders with their mobile phones.

In sogou, the ladies’ toilets are tense all the year round, and there are always long queues. With the help of infrared passive monitoring hardware, the system can detect whether there are people in the toilet and realize data transmission. At this time, you only need to open the small P, and you can see the crowded degree of each toilet.

Little P3.jpg.Interesting pit finding and personalized work card making.

For a large number of students who apply for a replacement work card, Xiao P connects them with the administrative department and the producer. As long as the photos submitted on the mobile phone pass the examination, they will be submitted to the producer. After the production is completed and sent back to the user, any information in the process will be updated in the small P information in real time.

Sheng Dehua： In the depths of Gobi, the spirit of Populus euphratica flourishes.

CCTV News:106 "missile soldiers" from the frontline of combat readiness training, national defense construction and operational support were promoted to the highest rank of soldiers with their superb professional skills. They took the "letter of appointment" from the general and put on a brand-new rank of first-class master sergeant. Sheng Dehua is one of them. He said that it is a special honor and pride to be promoted to the rank of first-class master sergeant and participate in the centralized awarding ceremony. We must take the goal of strengthening the army as the guide and continue to play our professional expertise in our posts to contribute to the upgrading of combat effectiveness.

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In June 1975, Sheng Dehua was born in an ordinary peasant family in Group 3, Chengwen Village, Caoyan Town, Dafeng City, Jiangsu Province. It was Sheng Dehua’s wish to be a soldier, and it was his dream in life to go to the battlefield.

Sheng Dehua joined the army in 1993, joined the party in July 1997, put on a green military uniform, entered the military camp, came to the Gobi Desert, and became a glorious plateau rocket soldier. Sheng Dehua’s shooting range post is located on the east side of Taklimakan Desert, 50 kilometers away from Fiona Fang. The surface temperature is as high as 50 degrees Celsius in summer, and the lowest temperature is MINUS 40 degrees Celsius in winter. It is windy and dusty all the year round, and there is no trace of green.

"The environment is bitter, but it is more important to work hard without suffering." Over the years, the spirit of plateau rocket soldiers has been inspiring Sheng Dehua. He and his comrades-in-arms have not been intimidated by the difficult environment and dangerous operations, and have always been meticulous in learning majors, practicing skills and building shooting ranges.

One day in May 2004, Sheng Dehua performed a dud removal task. Under the surface temperature of more than 50 degrees in the Gobi desert, he wore a bulletproof vest weighing 12 kilograms and an airtight bulletproof helmet, and drove an explosion-proof excavator to carry out the bomb disposal operation. After three hours of suffocating excavation, he finally completed the task. The fear is that a dud almost sticks to the inner wall on the right side of the bucket. If the bucket deviates from 10 cm, it is likely to trigger detonation, resulting in car crash and death.

seven

In order to strengthen the vigilance and flood control capability of the shooting range, in June 2010, he volunteered to the brigade leader to dig a warning flood control ditch around the shooting range. At that time, the melting water of the distant snow-capped mountains was coming. In order to catch up with the time, he got up first before dawn every day and worked against the stars and the moon at eleven or twelve in the evening. There was no place to stay, so he simply lived in the cave. One night, the quilt was blown away by the wind, and he chased it for hundreds of meters with a flashlight. During the day, when the temperature in the cockpit is as high as 40 degrees, he takes off his coat and works with bare arms. A month later, a 1.5-meter-deep, 2-meter-wide and 45-kilometer-long warning flood ditch was successfully completed. With excellent operation skills, he dug the flood control ditch as straight as a ruler in the Gobi without reference objects around. Leaders who have been to the shooting range will give a thumbs up: "There is this ‘ Great Wall ’ Guarding, the shooting range safety has nothing to say. "

In the military camp, Sheng Dehua was on duty, driver and position safety officer in a certain regiment’s security company. He also served as the monitor of the road maintenance class of the array company, and he was needed to operate eight types of large machinery such as excavators, elevators and bulldozers. Soldiers regard obeying orders as their bounden duty, and every time they change their posts, they take it easy.

seven

With enthusiasm and persistence, Sheng Dehua went deep into 12 points, including classes and posts, preached the spirit of the 18th National Congress for more than 600 officers and men for more than 20 times, conveyed the party’s voice with the real feelings of participating in the grand event, and answered the concerns of officers and men in military language, which narrowed the distance between everyone and the CPC Central Committee and strengthened the determination and will of the officers and men to take root in the plateau desert and make contributions to the military camp.

On the one hand, it is a lonely outpost, on the other hand, it is a prosperous and wealthy hometown, on the one hand, it is a job that you love, and on the other hand, it is a loved one who has always loved and deeply felt guilty. How to choose? "What makes this profession brilliant is not the military uniform, but the belief that it is hidden in the heart. As a contemporary revolutionary soldier, we must always insist on not abandoning our yearning for ideals and not giving up our persistence in faith. " This is the answer given by Sheng Dehua. (Source: CCTV News, Zhongqing Online)

School of Mathematics held the 6th Forum on Systems Science and a series of systematic seminars.

　　On October 18th,Institute of Mathematics and System Science, China Academy of SciencesInstitute of Systems ScienceSponsored"The 6th System Science Forum and Systematics Seminar Series"existMathematics collegeSouth building 204 lecture halllineAcademician Wan Zhexian, Academician Chen Hanfu, Academician Lin Qun, Academician Lin Huimin, Professor Fang Fukang, Professor Yu Jingyuan,Secretary of the Party Committee of Mathematics CollegeWang ShouyangandVice President Gao Xiaoshan and more than 140 experts, scholars and graduate students from inside and outside the hospital and Beijing.AttendedThis academic activity. This year coincides withThe 35th anniversary of the establishment of the Institute of Systems Science, this activityGather togetherSystem science forum, greenAcademic report in 2000 and "Systematic Seminar Series Activities" organized by Shanghai Academy of Science.The system science forum was presided over by researcher Yang Xiaoguang, deputy director of the Institute of Systems..

　　At the opening ceremony,Speech by Wang Shouyang.First of all, on behalf of the School of Mathematics, he congratulated the system on its 35th anniversary..Over the past 35 years, the system has trained a large number of outstanding talents for China, the world system science and related sciences, and made a series of achievements.haveThe work with important international influence has played an important role in national defense construction, economic security, industrial application and other fields. For the future development of the system institute, he pointed out that system science has great achievements. With the process of globalization, China’s further reform and opening up and the arrival of the era of big data, system science has more major development opportunities and is also facing new major challenges.;System science has its own development model, so we should respect the law, choose our own development strategy and cultivate more outstanding talents.

　　Subsequently, academician Lin Huimin and researcher Wang Shouyang, experts in computer software and theory, gave reports on "Odd-even Game and Model Checking" and "Talking from Rotterdam, the former largest port in the world" respectively.

　　Youth academic report bySystem instituteLi Hongbo, Assistant Director, presided over it..Three young backbone researchers Huang Yi, Yang Cuihong and Feng Xiutao from three key laboratories of the Institute of Systems made speeches respectively.Active Disturbance Rejection Control: Thought, Practice and Analysis》、《Talking about "Made in China"》、《Stream cipher: past, present and future"Report.

　　Director of the systemZhang Jifeng presided overSymposium on system science development.He thanked everyone for their support and help, summarized and reviewed the history and achievements of the system, and encouraged young researchers to work hard, take over the banner of the older generation and strive for greater achievements.The topic of the symposium on the development of systems science is to discuss the development, frontier problems and future trend of systems science. Professor Che Hongan of Shanghai University of Science and Technology gave a keynote speech "Thinking about what kind of innovation should be put forward by Mr. Wu Wenjun". Everyone talked passionately about the development of systematics, and the atmosphere was rich and warm.

　　Finally, Gao Xiaoshan made a concluding speech and introduced the situation of the center of Excellence to everyone.. hepoint out,Most of the achievements of the system come from the older generation of researchers, who have great hopes for young people and hope that everyone will work hard and continue the glory of the system.

　

　Seminar site

Resolutely rectify market chaos. In the past two years, the cumulative disposal of non-performing loans has exceeded 4 trillion yuan.

　　Cctv news: "Balance the relationship between steady growth and risk prevention. We are confident and capable of winning the battle to prevent and resolve financial risks. " On July 4th, the State Council held a press conference on the effectiveness of measures to promote the structural reform of the financial supply side. The relevant person in charge of China Banking and Insurance Regulatory Commission said that since the beginning of this year, China’s banking and insurance industry has continuously promoted the structural reform of the financial supply side, and the quality effect of financial services to the real economy has been continuously improved.

　　That night, "News Network" broadcast the relevant content. In fact, the conference also said a lot about preventing and defusing financial risks, especially what measures China Banking and Insurance Regulatory Commission has used and what results have been achieved in the past two years.

　　Positive progress has been made in preventing and resolving financial risks.

　　Liang Zhou, Vice Chairman of China Banking and Insurance Regulatory Commission, China, said that China Banking and Insurance Regulatory Commission dares to fight, take responsibility and confront difficulties, resolutely rectify market chaos and increase penalties. Over the past two years, more than 6 billion yuan has been confiscated, exceeding the total punishment in the previous ten years, and more than 8,000 people have been punished for violating the rules, which has formed a powerful shock.

　　Punishment is a means, not an end. The purpose is to force banks and insurance institutions to implement their main responsibilities through supervision and responsibility, maintain market order, protect the fundamental interests of the people, and firmly hold the bottom line that systemic financial risks do not occur.

　　With the efforts of all parties, the risks of high-risk institutions have been gradually resolved, and major cases of illegal fund-raising are being disposed of in an orderly manner. The effect of risk reduction in peer-to-peer lending is quite obvious.

　　The number of online lending institutions decreased by 57% compared with the beginning of 2018.

　　Unswervingly dismantle the high-risk shadow banks, and over the past two years, we have greatly reduced the high-risk financial assets with layers of nesting, complex structure and self-circulation by 13.74 trillion yuan, effectively curbing the financial reality.

　　At the same time, vigorously eradicate the soil of credit risk. In the past two years, the cumulative disposal of non-performing loans has exceeded 4 trillion yuan. At present, the non-performing loan ratio of the banking industry has stabilized at around 2%, and the provision coverage ratio has exceeded 175%. The main regulatory indicators such as the capital adequacy ratio of commercial banks and the comprehensive solvency adequacy ratio of insurance companies are at a good level.

　　Liang Zhou pointed out that "ammunition" to resist risks is sufficient. Financial risks have gradually turned from divergence to convergence, which is generally controllable.

　　Liang Zhou also said that he was clearly aware that there were still many gaps and deficiencies in the banking and insurance industry. If you want to understand and say it clearly, you must finally implement it. In the next step, China Banking and Insurance Regulatory Commission will continue to deepen the structural reform of the financial supply side, focus on enhancing the ability of financial services to the real economy, deepen financial reform and opening up, and balance the relationship between steady growth and risk prevention.

　　"We are confident and capable of winning the tough battle to prevent and resolve financial risks, promoting the continuous development of the banking and insurance industry to high quality, and providing stronger financial support for building a well-off society in an all-round way." Liang Zhou said firmly.

　　Cure chaos, make up shortcomings, maintain high-pressure situation, and rectify according to laws and regulations.

　　Liang Tao, Vice Chairman of China Banking and Insurance Regulatory Commission, China, made supplementary remarks on the work of dealing with chaos and making up shortcomings in the insurance industry. He said that in recent years, due to various reasons, China’s insurance institutions have experienced a rapid development stage, and there have also been blind expansion and chaos. Chaos is mainly manifested in weak corporate governance, illegal use of funds, improper product innovation, misleading sales, untrue financial business data and so on.

　　After the Party Committee of China Banking and Insurance Regulatory Commission was formally established, in May 2018, a meeting was held to promote the work of deepening the rectification of chaos in the banking and insurance markets. Require a comprehensive self-examination, leaving no dead ends. Deploy all insurance institutions to focus on the rectification of market chaos, check their own problems and make serious rectification.

　　The regulatory authorities also focused on key points and carried out regulatory inspections in a solid manner. In 2018, the regulatory authorities conducted 1,466 inspections of insurance institutions, with a total investment of 9,793 person-times. This year, the regulatory authorities at all levels continue to pay attention to the outstanding risks and problems in the insurance industry, and are now entering the market one after another to carry out inspections, which mainly cover corporate governance, solvency, capital utilization, auto insurance, agricultural insurance, short-term health insurance and so on.

　　Through strict punishment according to the law and regulations, we will maintain a high-pressure situation. In particular, the double penalty system has been implemented, and the punishment for senior executives has been strengthened. Various punishment measures have been taken comprehensively, such as limiting the business scope, ordering to stop accepting new business, revoking business licenses, revoking qualifications, and prohibiting entry into the insurance industry, so as to effectively increase the cost of violating laws and regulations, making institutions afraid, unable and unwilling to violate regulations.

　　Through continuous rectification, obvious results have been achieved, and the chaos in the insurance market has been corrected to a great extent.

　　Powerful shock the illegal subject. From January to May this year, 277 insurance institutions were punished, and institutions were fined more than 44 million yuan, ordered to stop accepting new business for 15 times, and their business licenses were revoked for 2 times. 416 responsible persons were punished, individuals were fined nearly 16 million yuan, and 18 people were disqualified.

　　The shortcomings of the system have been effectively compensated. Since 2018, more than 20 regulations and normative documents have been revised. Some problems such as lag, absence, overlapping and conflict have been effectively solved, and the institutional systems in key areas such as corporate governance, capital utilization, product management, consumer rights protection and self-construction of regulatory capacity have been further improved and perfected.

　　There are major risks in institutions, and the failure of corporate governance is an important reason.

　　Corporate governance is the "bull’s nose" for banks and insurance institutions to prevent risks and develop steadily. Many institutions have major risks, and the failure of corporate governance is an important reason. Some reporters have raised relevant questions.

　　In response to a question, Liang Tao said that some time ago, some cases occurred in the financial field, reflecting some outstanding problems in corporate governance of some operating institutions, mainly manifested in opaque and irregular equity relations, such as the problem of holding shares on behalf of others; There is also extensive management of related party transactions, and there is a problem of interest transfer; The development strategy blindly pursues extensive expansion, and the internal control does not match the development speed. In some institutions, the equity management is chaotic, the governance mechanism is ineffective, the "three meetings and one layer" is ineffective, and risks are accumulating.

　　China Banking and Insurance Regulatory Commission attaches great importance to corporate governance. Since the establishment of China Banking and Insurance Regulatory Commission in late March 2018, a symposium on corporate governance of small and medium-sized banks and insurance institutions was held in April to improve the corporate governance mechanism, organize research and deployment of banking and insurance industries.

　　After the promulgation of the "three-set plan", the corporate governance supervision department was set up to co-ordinate the corporate governance supervision of banks and insurance industries. By filling the shortcomings of the system, strengthening inspection and evaluation, and strengthening accountability, we will continue to promote the banking and insurance industries to improve the compliance and effectiveness of corporate governance. In the practice of supervision, we will implement differentiated supervision for different institutions according to specific conditions.

　　For large state-owned banks and insurance companies, we should improve the contents, rules and procedures of "three majors and one big" decision-making. For small and medium-sized commercial banks and insurance companies, we will focus on rectifying the chaos of shareholders’ equity and management transactions, and severely crack down on violations of shareholders’ equity and the transfer of benefits through illegal related party transactions.

　　In the next step, China Banking and Insurance Regulatory Commission will focus on improving the effectiveness of corporate governance of banking and insurance institutions, and continue to strengthen corporate governance supervision. First, make up for the shortcomings of corporate governance supervision system, improve the supervision system of corporate governance in banking and insurance industry, and fill the shortcomings in corporate governance mechanism, equity management and transaction management. The second is to evaluate the corporate governance of banking and insurance institutions, and rectify and implement the problems found. The third is to promote the construction of information system of corporate governance supervision, and improve the information level and scientific level of corporate governance supervision.

　　After low interest rate funds are lent to enterprises, the relevant funds are used for arbitrage.

　　In the first five months of this year, the average interest rate of new loans for inclusive small and micro enterprises issued by five large commercial banks was 4.79%, which was 0.65 percentage points lower than the average level of last year. Some people worry that the interest rate is too low and will not be sustainable in the future. Yang Liping, chief procurator of China Banking and Insurance Regulatory Commission, China, answered this question by herself when answering a reporter’s question. She said that it can be analyzed from the following aspects:

　　From the positioning point of view, large banks issue loans to small and micro enterprises, and the positioning is to protect capital and make small profits. By strengthening cost accounting, improving risk control and constantly improving products and services, banks position micro-financial services as protecting capital and making small profits.

　　Second, the state has given preferential policies for loans to small and micro enterprises. For example, the People’s Bank of China implemented the targeted cuts to required reserve ratios in inclusive finance to create targeted medium-term lending facilities, and the finance and taxation departments also have relevant policies, all of which are required to be reflected in the loan pricing of small and micro enterprises.

　　Third, through big data and cloud computing, large banks can identify risks more accurately and reduce excessive dependence on mortgage guarantees, thus reducing their own capital costs, operating costs and risk costs.

　　Finally, she added that the relevant departments also noticed that there were very few cases in the supervision practice. After individual banks lent low-interest funds to enterprises, the relevant funds were used for arbitrage and bought wealth management products. In this regard, banks are also required to strengthen the management of loan flow, so that low-cost funds will not be misappropriated and better serve small and micro enterprises.

　　In the next step, we will continue to promote services related to small and micro enterprises, including formulating an evaluation system and conducting unannounced visits to enterprises. We will conduct unannounced visits to enterprises in July, August and September this year.

Ranking and price of top ten famous brands of hybrid cars

The following are the top ten brand names and prices of hybrid cars:

1. BYD Han: It is equipped with a blade battery independently developed by BYD, with a battery capacity of 64.8kwh. The pure electric cruising range of its hybrid model is 101km-202km, and the price is 219,800-329,800 yuan.

2. Latte DHT-PHEV: The price is 229,000-263,000 yuan, equipped with 1.5T plug-in hybrid power, and the pure electric cruising range is 80km-184km.

3. Emgrand L: The price is 129,800-145,800 yuan, equipped with 1.5T plug-in hybrid power, and the pure electric cruising range is 80km-150km.

4. destroyer 05: the price is 121,800-159,800 yuan, equipped with 1.5T plug-in hybrid power, and the pure electric cruising range is 46km-101km.

5. Auchan Z6 New Energy: The price is 155,800-175,800 yuan, equipped with 1.5T plug-in hybrid power, and the pure electric cruising range is 55km-150km.

6. Roewe RX5MAX new energy: The price is 169,800 yuan-189,800 yuan, equipped with 1.5T plug-in hybrid power, and the pure electric cruising range is 54km-100km.

7. Latte DHT: The price is 159,800-179,800 yuan, equipped with 1.5T oil-electricity hybrid, and the comprehensive fuel consumption is 4.9L/100km.

8. Question M5: The price is 259,800-331,800 yuan, equipped with extended-range hybrid, and the pure electric cruising range is 150km-200km.

9. Destroyer 07: The price is 196,800-242,800 yuan, equipped with 1.5T plug-in hybrid power, and the pure electric cruising range is 60km-205km.

10. frigate 07: the price is 202,800-342,800 yuan, equipped with 1.5T plug-in hybrid power, and the pure electric cruising range is 46km-205km.

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The above are the top ten brand names and prices of hybrid cars for your reference.