Hefei implements the ＂trinity＂ layout of vehicle, parts and aftermarket, and accelerates the construction of new energy vehicle capital.

Recently, the cooperation between Volkswagen and Hefei has reached a new level. According to the agreement signed between audi ag (China) and Hefei Economic Development Zone, the project of Volkswagen (China) Technology Co., Ltd. with a total investment of nearly 1 billion euros has settled in Hefei Economic Development Zone. The project integrates vehicle R&D, spare parts R&D and procurement, and will become audi ag’s largest technology and innovation center in China.

At present, Hefei has cultivated and introduced six new energy vehicle manufacturers, including Volkswagen, BYD, Weilai, Jianghuai, Chang ‘an and An Kai, and gathered more than 500 supporting enterprises, including Guoxuan Hi-Tech, Zhongchuang Singapore Airlines and Juyi Technology. Last year, the output of new energy vehicles in the city was 255,000, a year-on-year increase of 133%, and the output value of the whole industrial chain reached 120 billion yuan. In the first five months of this year, the output of new energy vehicles was 230,000, a year-on-year increase of more than four times.

Driven by "whole vehicle", grab the commanding heights of the industry

In the second advanced manufacturing base of Weilai in Hefei Xinqiao Intelligent Electric Vehicle Industrial Park, the production line is full of horsepower. In the four process workshops of stamping, car body, painting and final assembly, the long arm of machinery flies up and down, and a new energy vehicle goes off the assembly line every minute.

"The industrial park can accommodate more than 10,000 R&D personnel and more than 40,000 skilled workers. The planned vehicle production capacity is 1 million vehicles/year and the battery production capacity is 100GWh/ year. The estimated annual output value is 500 billion yuan." The relevant person in charge of Xinqiao Intelligent Electric Vehicle Industrial Park said that this year, in addition to delivering the new ES8 and EC7 of the full-scene intelligent electric flagship SUV, Weilai will also launch three new models of the second-generation technology platform. At that time, the number of models on sale will reach 8.

BYD’s Hefei production base in Xiatang Town, Changfeng County is also booming, and the best-selling models such as "Qin" series and "Yuan" are being sold all over the country from here.

After the completion of the first, second and third phases of BYD Hefei Base, the annual output value will be nearly 200 billion yuan, which will drive the total output value of the upstream and downstream industrial chains to not less than 300 billion yuan. At present, the third phase of BYD has been completed and put into production, and the total output has exceeded that of last year.

"Adhere to the concept of’ serving existing enterprises well is the best way to attract investment’, and strive to create a national new energy automobile industry cluster with the existing six vehicle companies as the traction." At the promotion meeting of new energy automobile industry cluster construction in the province held recently, the main person in charge of Hefei Municipal Committee said.

Hefei goes all out to serve the vehicle head enterprises. Concentrate on supporting existing enterprises, promote major projects such as BYD Hefei manufacturing base, Volkswagen’s second global R&D center and Weilai Xinqiao Industrial Park, and encourage enterprises to increase capital and expand production one after another. Concentrate on building industrial bases, build three "million-vehicle" production bases in Xiatang, Xinqiao and Xingang, and build a number of "10 billion-level" parts parks. Concentrate on cultivating industrial ecology, introduce an action plan to accelerate the construction of a new energy automobile capital, integrate the new energy automobile industry fund with a total scale of over 100 billion yuan, and give enterprises full-cycle and all-factor policy support.

The relevant person in charge of Hefei Economic and Information Bureau introduced that by 2025, the city’s new energy vehicle production capacity will exceed 3 million, and the industrial scale will reach "trillion level" by 2027.

Chain extension and chain supplement, magnetic attraction industry "upstream and downstream"

At the beginning of July, Hefei held the second special event of automobile industry chain of industrial integration matchmaking meeting. At the docking meeting, more than 40 enterprises, including Vodafone Semiconductor, Zhixin Semiconductor and Iflytek, docked around the key problems in the industrial chain of new energy vehicles. Since last year, Hefei has organized more than 20 global smart car industry summits and other activities, attracting more than 700 industrial chain enterprises at home and abroad to participate.

Do a good job in the "big article" of new energy automobile parts and components, and Hefei will further sort out and improve the "three maps" of the new energy automobile industry chain: industrial panorama, regional distribution map and investment promotion construction drawing, and continuously promote the chain extension and chain reinforcement. On this basis, the supply and demand docking such as "zero coordination", "core-car coordination" and "smart-car coordination" will be carried out in a normal way, and the industrial chain integration development policy will be introduced, and the heads’ meeting of key enterprises, the industrial chain suppliers’ meeting and the project element guarantee meeting will be held well. At the same time, join hands with the sister cities in the province to build an industrial ecology of integrated clusters. On the basis of moderately advanced supporting infrastructure, we will promote the construction of three-level charging and replacing systems at county, township and village levels.

At present, Hefei has laid out several automobile industry parts parks in Hefei High-tech Zone, Baohe District, Lujiang County, Feidong County, Chaohu City and Anchao Economic Development Zone. "It is precisely because we have identified the business track of intelligent equipment and electric control parts of new energy vehicles. The company’s products and technical services have directly entered world-class enterprises such as Volkswagen, Tesla, Jaguar Land Rover and Honda, and initially realized the internationalization strategy of enterprises." The person in charge of Anhui Juyi Technology Co., Ltd. said.

Since last year, Hefei has joined hands with its sister cities to promote Midea Weiling Auto Parts Project with a total investment of over 10 billion yuan to settle in Anqing, BYD Auto Parts Industrial Park with a total investment of over 10 billion yuan to settle in Fuyang, and Weilai Vehicle Phase II and other related projects will also settle in Hefei Xinqiao Science and Technology Innovation Demonstration Zone (Hehuai Cooperation Zone). It is understood that the near-ground matching rate of Volkswagen Anhui has reached 70%. About 70% of Weilai’s supply chain partners are located within 600 kilometers from Hefei.

Multi-pronged approach to make the industry "ecological circle"

Leading by the leading enterprises and supporting, Hefei’s automobile enterprise industry "forest" scenic spot is formed, in which "big enterprises are indomitable and small enterprises are overwhelming". The prosperity and growth of industry can not be separated from the cultivation and feedback of "post-market" and the nourishment of excellent industrial ecology.

At the intersection of Shixin Road and Susong Road in Hefei, a white building with unique appearance is very eye-catching. This is the first new energy vehicle charging complex project in this city, which was put into trial operation not long ago. There are 197 parking spaces, including 185 parking spaces for car charging piles and 12 parking spaces for large truck charging piles. "Not only can it be sheltered from the wind and rain, but the car charging process is also safer. Moreover, the number of charging parking spaces is sufficient, and there is generally no need to wait in line. " A car owner who is charging said.

In recent years, Hefei has made great efforts to build a public charging network with "government guidance, unified supervision, reasonable layout and moderate advancement". According to statistics, as of May this year, Hefei has built 84,800 charging facilities of various types, initially forming a 2-kilometer charging service circle in the urban area, which can meet the daily charging demand of about 210,000 new energy vehicles.

"With sufficient sources of funds, the company’s development is booming, with sales revenue increasing by 30% in the first half of the year." Xie Weifen, deputy general manager of Hefei Shengtaike Automotive Electronics Co., Ltd. said happily.

Shengtaike Company is an intelligent networked automobile core sensor and system integration solution provider. Last year, due to expanding production capacity and increasing investment in research and development, liquidity was tight. The investment team of Hefei Xingtai Holding Fund communicated and coordinated many times, and completed the investment in Shengtaike project at the end of last year, totaling 41.13 million yuan.

In order to strengthen the full-cycle and all-factor policy support for enterprises, Hefei has introduced special policies such as accelerating the development of new energy automobile industry and further promoting the promotion and application of new energy intelligent networked vehicles; Upgrade the "fund+industry", "fund+base" and "fund+project" driving mode, and integrate the new energy automobile industry fund with a total scale of over 100 billion yuan.

Release the new energy vehicle consumption subsidy policy, with a maximum subsidy of 5,000 yuan; Continue to promote the construction of recycling system for power batteries, and encourage leading enterprises to tackle key technical problems … In recent years, Hefei has made frequent efforts to optimize the "ecological circle" of new energy vehicles and make the "aftermarket" bigger and stronger.

"We will extend from focusing on manufacturing to’ products+services’, focusing on five aspects: exhibition, financial services, testing services, used car trading and battery recycling, logistics and export, so as to expand the automobile aftermarket as soon as possible." The main person in charge of Hefei Municipal Committee said. (Xu Genhong, Feng Jing, Xu Beibei)

Guangxi Baise： You can’t drive up prices and raise prices at will! Being warned that it has not been rectified will be strictly investigated according to law.

　　Guangxi Baise Municipal Market Supervision Administration issued a notice on February 7, in order to standardize the market price order during the epidemic prevention and control in 2022, safeguard the legitimate rights and interests of consumers, promote operators and relevant units to strictly abide by the price laws, regulations and policies, and prevent all kinds of price violations, we hereby remind all operators and relevant units in the city as follows:

　　1. All business operators and relevant units should strictly abide by the price laws, regulations and policies such as People’s Republic of China (PRC) Price Law, Provisions on Clearly Marking Goods and Services and Provisions on Prohibiting Price Fraud, consciously enhance their sense of social responsibility, and conscientiously implement price self-discipline.

　　2. All operators and relevant units should follow the pricing principles of fairness, legality, honesty and credit, and provide consumers with goods and services with qualified quality and reasonable price.

　　3, the operators and relevant units should seriously regulate the commodity pricing behavior, so that the price tag, and publicity in a prominent position; It is forbidden to collude with each other, manipulate market prices, hoard, drive up prices, and spread rumors of price increases to seek illegal interests.

　　4. Operators of shopping malls, supermarkets, farmers’ markets and e-commerce platforms shall fulfill their price commitments and shall not raise prices at will; It is not allowed to mislead consumers into trading by misleading pricing methods such as fictitious original price and false discount.

　　5. Oil and natural gas operators (gas stations and liquefied natural gas stores) should actively organize the supply of goods to ensure market supply, and must not abuse their dominant market position to drive up prices and disrupt the price order of oil and natural gas markets.

　　6. Medical institutions and pharmaceutical trading enterprises should publicize the charges and clearly mark the prices according to the regulations, publicize the charging standards of medical services and drug prices in a conspicuous position, and shall not arbitrarily raise prices or charge fees in violation of regulations.

　　All operators and relevant units should attach great importance to it and comprehensively rectify their own irregular price behaviors. Those who have not been rectified after being warned will be severely punished according to law, and typical cases will be publicly exposed through the news media. Consumers and all sectors of society are welcome to supervise the price behaviors of relevant operators and units. If price violations are found, please keep relevant evidence and call the consumer complaint telephone number 12315 or 12345 to make a complaint and report in time. (Headquarters reporter Liao Wei, Liu Chang, Ryson Ho)

Girls in the flower season want to buy a lot of sleeping pills online. The customer service noticed that something was wrong and quietly reported the police.

　　Shanxi Evening News (Reporter Xin Ge correspondent Wang Shuanghong) "I just want to buy a lot of sleeping pills. Just sell them to me, and don’t worry about the rest." Faced with the girl’s online shopping requirements, careful online customer service noticed that the girl might have suicidal tendencies and quietly chose to call the police. On December 18th, Shanxi Evening News reporter learned from Xinghualing Branch of Taiyuan Public Security Bureau that a teenage girl who was planning to commit suicide was successfully rescued because of the timely alarm.

　　At 12: 39 on December 17th, Xinghualing Branch of Taiyuan Public Security Bureau received the "110" warning instruction from the Municipal Bureau, saying that it had received an alarm from the staff of a shopping website. It turned out that on the evening of 16th, a woman in a dormitory in Dadongguan North Lane, the provincial capital, wanted to buy a lot of sleeping pills on the shopping website. After communicating with it, the customer service staff found that the woman was suicidal. For this reason, the customer service did not agree or reject the woman’s purchase application, but quietly reported the police.

　　After receiving the warning instructions, in order to gain time, the police of Dadongguan police station worked in multiple ways at the same time, and all the police officers immediately rushed to the neighborhood to find the woman through the residential property; The police all the way contacted the customer service of the shopping website to learn more about more valuable information clues. Through the information collected by many parties, the police finally verified that the woman who planned to buy a large number of sleeping pills online was a female student under the age of 18.

　　"We arrived at the girl’s house at 1 noon that day, knocked on the door in a hurry, and saw that the girl and her mother were at home. This hanging heart was put down." According to the police, in the communication with the girl’s mother, the police learned that there were changes in the girl’s family, and her mother usually paid less attention to her children, which led to the girl’s suicidal thoughts. In this regard, the child’s mother is unaware of it. Subsequently, the policewoman communicated with the girl and learned that the girl was introverted and unwilling to talk. The police have narrowed the distance with girls by telling stories about such police experiences they usually encounter when they go out to the police. The girl began to communicate with the police, saying that she was under great pressure of study, and there were changes at home, so she couldn’t get over the idea of suicide. On the evening of 16th, she tried to commit suicide by buying sleeping pills online, but she didn’t buy them. To this end, she is preparing to go to a nearby drugstore to buy it in the afternoon.

　　"In the future, no matter what you encounter in your study and life, you can call me at any time." After nearly an hour of communication between the police and the girl, the girl who intends to commit suicide said that her heart knot has been opened and she will not do stupid things again in the future. When she left, the policewoman gave the girl her mobile phone number.

Four post-80s self-made Braille picture books let blind children ＂see pictures＂

　　They are the staff of Chongqing Library. It took them half a year to produce the first batch of 50 books, and they plan to complete another 50 books this year.

　　The most beautiful worker

　　Editor’s Note: They are a group of ordinary people who have interpreted the oath of "the most glorious work" with decades of persistence and dedication; They are a group of ordinary people who have made extraordinary achievements in their ordinary posts and become "the most beautiful workers". On the occasion of the May 1 International Labor Day, this newspaper launched a series of advanced typical reports on "the most beautiful workers", and approached some workers who won the title of national model workers and advanced workers in 2015 to see how they can contribute to society with diligence, wisdom, knowledge and skills.

　　Let blind children "see pictures" and feel the charm of pictures. This is the wish of four post-80s staff in Chongqing Library, namely Xu Yaoyao, director of the visually impaired reading room, Liu Xinju, assistant director, Hu Rong and Ye Jing.

　　In order to realize this wish, they spent half a year making their own Braille picture books. Recently, the first batch of 50 Braille picture books were printed, which is also the first batch of Braille picture books in China.

　　Mother-child dialogue triggers production ideas

　　"Because of working in the visually impaired reading room for a long time, we spend a lot of time in contact with blind children." Xu Yaoyao said that after a long time of contact, they found that most of the books read by blind children were Braille, with no pictures, and the form was relatively simple and boring.

　　Last March, a mother took her child to the reading room to read a book. The child read a book about various plants. "He asked his mother, what color are the roses?" The mother told her son, "Roses are red."

　　Xu Yaoyao, who witnessed this scene with his own eyes, was sour. What is obvious to many children has become so difficult for these children with eye diseases. This gave Xu Yao Yao the idea of making "Braille picture books".

　　Let the picture come alive in the child’s mind

　　What is a Braille picture book? Xu Yaoyao said that the purpose of Braille picture books is to tell the contents of pictures in Braille in vivid language, so that children can "read" and give full play to their imagination to form pictures in their own minds.

　　How to turn pictures into vivid words? "Because only by telling the content of the picture vividly in words can we arouse children’s imagination and play the role of a picture book." Therefore, four people sometimes argue for hours in order to write a good picture.

　　"Whether the color description of the picture can be richer or not depends on how to add it to the picture description, which is the most controversial place for everyone." Liu Xinju said. For example, the description of color is too monotonous if it is only described as "red, orange, yellow, green, blue and purple".

　　Xu Yaoyao said that the color words in an ancient Chinese prose from the perspective of Weibo helped. In this chart, blue can be divided into indigo, indigo, azure, blue, snow blue, blue gray, navy blue, purplish blue, indigo and so on. "With these colors, the world of Braille picture books will be colorful at once."

　　It takes half a month to translate a thousand-word picture book.

　　In addition to color, the production of braille picture books requires the use of braille, and the requirements are higher.

　　But the four of them don’t know Braille at all. What should we do?

　　Xu Yaoyao said, first of all, they translated the characters into corresponding Braille through software and then printed them out. The next step is the most time-consuming part: take the printed Braille, open the dictionary, and check whether the blind spots are arranged incorrectly one by one. "It takes almost an hour to verify a sentence of less than 20 words."

　　Ye Jing felt deeply about this job: after reading Braille for a long time, not only his eyes were sore, but he looked up at everything and couldn’t focus for dozens of seconds. Take Reunion as an example, there are 1,192 characters, that is, more than 7,000 blind spots. Coupled with their own pictures, they need at least tens of thousands of blind spots. It took only half a month to translate this braille picture book.

　　More volunteers are needed to join in.

　　After proofreading all the Braille, you need to scan them into the computer and print them out by a special Braille printer. After Braille is printed, it is cut and pasted near the corresponding words and pictures of children’s picture books, and the picture books are finished.

　　"The cost of making a Braille picture book is not low." Xu Yaoyao said, Take Reunion as an example, a book with 39 pages costs about 780 yuan. After learning about their production of Braille picture books, the library solved all the expenses.

　　From last summer vacation to this month, it took them half a year to finally complete the production of 50 Braille picture books. "At present, all these picture books have been put on shelves in the visually impaired reading room, and blind children can borrow them from the reading room."

　　For the blind children in the city, the number of these picture books is still too small. "We have another wish." Xu Yaoyao said that more braille picture books should be made to meet the reading needs of more children with visual disabilities. It is planned to complete another 50 books this year. Of course, they also urgently need volunteers who know Braille to join. (Reporter Li Sheng reports)

(Source: chongqing morning post)

Farewell ceremony of Zhang Hanzhi’s body was held in Babaoshan.






The picture shows Zhang Hanzhi’s daughter Hong Huang (middle) walking out of the mourning hall with her mother’s portrait in her hand after the farewell ceremony.







The picture shows Zhang Hanzhi’s daughter Hong Huang (right) stepping on the hearse to see her mother off after the farewell ceremony.


　　On February 1st, a farewell ceremony for the body of Zhang Hanzhi, one of China’s outstanding diplomats in the 1970s and a generation of celebrities, was held in Babaoshan, Beijing. Hundreds of relatives and friends from Zhang Hanzhi and celebrities from all walks of life went to bid farewell. Zhang Hanzhi, the adopted daughter of Zhang Shizhao, a well-known democrat, died on January 26th this year at the age of 73. Zhang Hanzhi used to be an English teacher in Mao Zedong and was the wife of Qiao Guanhua, a famous diplomat in China. China News Agency issued Zou Xian photo


Related news:


After the famous family, Zhang Hanzhi died as Mrs. Qiao Guanhua, the former foreign minister (photo)


Celebrity Zhang Hanzhi left an unfinished autobiography as a teacher of Mao Zedong.


Zhang Hanzhi recalled the ice-breaking trip between China and the United States: more than 100,000 people swept the snow and touched Nixon.


The special love between Zhang Hanzhi and Qiao Guanhua originated from Chairman Mao’s criticism.


























More eye-catching news:
What are the descendants of China’s top ten marshals doing? (figure)
Zhang Hanzhi’s memorial service will be held in Beijing on February 1 and will be buried with Zhang Shizhao.
In the cold, Hu Jintao inspected the supply of coal in Shanxi and Hebei.
Netizen voted Premier Wen, the most touching figure in Spring Festival travel rush, top the list (photo)
Let’s be amazed at the top ten beauties of the Spring Festival Evening.
11 people were buried in the basketball hall of Xianning University in Hubei Province when the snow collapsed (Figure)
Wang Wulong, former deputy director of Jiangsu People’s Congress, received a reprieve for accepting bribes of 6.83 million yuan.
The public security organ said that the abolition of the first-generation ID card in 2008 was a rumor.
The final conclusion of Taiwan Province’s "True Mediation" is: "3? 19 shooting "is" fake "
14 actresses involved in Edison Chen’s erotic photos. Hong Kong police arrested a suspect.

Editor: Yin Wei

Empowering the sustainable development of creative industries, where is the new productivity cow？

Empowering the sustainable development of creative industries, where is the new productivity cow?

　　Whenever we talk about the new quality productivity in the cultural field, we can’t avoid digital travel, virtual exhibition, immersive experience scene, AI big model & HELIP; … With the rapid development of science and technology and the continuous improvement of people’s spiritual and cultural needs, new quality productivity in these cultural fields has gradually emerged.A new cultural format with digital as the carrier, Internet as the space and information technology as the tool has sprung up.. How does the new quality productivity empower the cultural and creative industries, and what opportunities and challenges have it brought? In the international market, how does new quality productivity help creative industries to make progress towards sustainable goals?

　　One,How can new quality productivity empower the development of cultural and creative industries?

　　In the era of new quality productivity, intelligence and creativity have become the key variables of wealth creation, and the brand-new economic development model and value creation logic have promoted the continuous renewal and evolution of new quality productivity in the cultural field.

Empowering the sustainable development of creative industries, where is the new productivity cow?

Logical relationship diagram of new quality productivity Source: CCTV News

　　The new quality productivity in the cultural field refers to the advanced productivity with obvious characteristics of innovation-driven, high-tech support, high efficiency and high quality in the process of cultural production and dissemination, covering technological innovation, content creativity, new format development, personnel training and so on, which can promote cultural inheritance and innovation while meeting people’s needs for a better life.

　　Digitalization and information technology promote the sustainable development of cultural industry.Through technologies such as 5G, VR/AR, augmented reality and AI big model, culture has "come alive" in the digital world. For example, museums, entertainment spaces and other places develop digital products and services to promote the creation, production and dissemination to the "cloud" side; Using digital technology, digital model making and 3D realistic restoration of cultural relics are carried out to realize creative transformation and sustainable development.

Empowering the sustainable development of creative industries, where is the new productivity cow?

The High-tech Interactive Exhibition of the Forbidden City "The Riverside Scene at Qingming Festival 3.0" Source: Official Weibo of the Palace Museum.

　　Intelligentization and networking improve the development efficiency of cultural tourism industry.Intelligentization is mainly reflected in improving the efficient and smooth operation of cultural tourism activities through intelligent monitoring and management; Using AI technology to improve the efficiency and quality of cultural tourism content creation; Enhance the consumption experience of cultural tourism through technological innovation and smart tourism, and realize e-tickets, "cloud" queues, and smart tours.

Empowering the sustainable development of creative industries, where is the new productivity cow?

"One Mind, Stars" Immersive Art Experience Exhibition Source: Xinhuanet

　　Cross-border integration of new formats helps the diversified development of cultural industries.Cross-border integration is an important manifestation of new quality productivity in the field of cultural and creative work. Through the ingenious combination of elements in different fields, such as the integration of traditional crafts and modern design, we can create cultural and creative products with both value and cultural connotation. The cross-border integration of new formats also includes the creation of new consumption scenes, the integration of online and offline consumption, and the development of emerging industries such as online audio-visual, digital publishing, online education and digital animation.

Empowering the sustainable development of creative industries, where is the new productivity cow?

Digital Creation of "Royal Jinbei" Source: Official Weibo of Shaanxi History Museum

　　Innovation and application of industrial chain accelerate cultural inheritance and innovation.Cultural industries related to new quality productivity include strategic emerging industries, national science and technology service industries, core industries of digital economy, "three new" economic activities and high-tech industries. Improving the stability and competitiveness of the industrial chain and building a smart industrial chain system will promote the deep integration of the cultural industrial chain with the Internet and the Internet of Things, and accelerate cultural inheritance and innovation.

　　Second, the new quality productivity in industrial practice

　　The application of new quality productivity can always provide new kinetic energy for the cultural industry, such as producing more competitive high-end products, accelerating the research and development of new products and services, optimizing the allocation of production resources, stimulating the vitality of industry development, empowering the industry to improve quality and efficiency, and promoting industrial transformation and upgrading, thus achieving sustainable development.

　　Although the application of new quality productivity has brought development opportunities for cultural and creative industries, it also faces some challenges. With rapid technological upgrading and short innovation cycle, it is difficult for cultural and creative enterprises to keep up with the pace; Problems such as talent shortage and imperfect intellectual property protection in cultural and creative enterprises also restrict industrial development, including fierce market competition, serious homogenization of products and services, and insufficient innovation ability and so on. Through the following excellent cases at home and abroad, let’s look at how the cultural and creative industries skillfully use new quality productivity to break the development dilemma.

　　1、Digital Dunhuang: AI meets Dunhuang through the Millennium

　　In the Mogao Grottoes, I picked up my mobile phone and the nine-color deer wearing ribbons "flew out" from the murals. Touch it, and the nine-color deer will twist and say hello. Scenes of interaction among people, caves and virtual images often appear in Mogao Grottoes. In recent years, the protection and research of Dunhuang culture has broken through the development dilemma and ushered in a bright future. "Digital Dunhuang" has changed from a dream to a reality.

Empowering the sustainable development of creative industries, where is the new productivity cow?

Dunhuang Buddhist Statues Replicated by 3D Printing Technology Source: Xinhua News Agency

　　The "Digital Dunhuang" project uses advanced science and technology and the concept of cultural relics protection to comprehensively collect, process and store the Dunhuang grottoes and related cultural relics digitally, and collect the obtained and to-be-obtained images, videos, three-dimensional and other literature data, so as to build a diversified and intelligent digital resource library of grottoes, share it with the world through the Internet, and establish a digital asset management system and a digital resource science guarantee system. Up to now, the murals of 30 caves have been fully digitized.

　　The "Digital Tibetan Sutra Cave" innovatively launched by Dunhuang Research Institute uses cutting-edge technologies such as high-definition digital scanning and physical rendering of game engines to vividly reproduce the historical scenes of Dunhuang Tibetan Sutra Cave and its 60,000 volumes of precious cultural relics with 4K film and television quality, and combine the modern meticulous painting art scenes with the gamification interaction mechanism in Chinese style, so that users at home and abroad can enjoy Dunhuang culture in an immersive way. Therefore, the "Digital Sutra Cave" has become the first "super-time participatory museum" built by using game technology in the world.

Empowering the sustainable development of creative industries, where is the new productivity cow?

Virtual digital man Jia Yao (inspired by the wonderful bird Jia Ling Pin Jia in Dunhuang murals) Source: Dunhuang Research Institute.

　　In addition, Dunhuang Research Institute also launched the smart scenic spot applet, created the "official virtual human of Dunhuang Mogao Grottoes" Gayao, and produced the 8K high-resolution dome movie "Dream Buddha Palace". Based on the vast resources of "Digital Dunhuang", Dunhuang Research Institute is equivalent to creating a virtual "twin world" in the Mogao Grottoes, and realizing "seeing the cultural relics inside the grottoes outside". With the blessing of digital technology, Dunhuang culture, which is visible, audible, sensible and tangible, has opened up imaginative cultural applications, attracting more people to approach the Mogao Grottoes and understand the splendid Chinese culture.

　 　 　 　2. Shougang No.1 Blast Furnace ·SoReal Science Fiction Park: Opening an "Interstellar Journey" at an industrial site.

　　Shougang No.1 Blast Furnace, which once had a hundred years of industrial history, has done a good job in industrial innovation with the help of new quality productivity, and now it has become a sci-fi space where reality and reality are intertwined, and it has become one of the representatives of urban renewal and industrial transformation and upgrading.

Empowering the sustainable development of creative industries, where is the new productivity cow?

A blast furnace ·SoReal Science Fiction Park Interior Source: Shougang Group official website

　　Shougang No.1 Blast Furnace ·SoReal Science Fiction Park is the world’s first fully-immersed science fiction complex integrating culture, science and technology, entertainment and consumption. The future space of 33 META CLUB in the venue is a multi-functional composite space integrating cultural exhibitions, event releases, e-sports events, performing arts and music bars. The original architectural structure and industrial features are preserved to the maximum extent in the renovation and design, and Cyberpunk design elements, modern lighting and dancing beauty and XR extended reality immersion experience technology are integrated to reshape the meta-space.

　　Based on China’s sci-fi stories, Science Fiction Park has widely deployed innovative technologies such as 5G, cloud computing, AR, VR, MR, AI, digital twins, 3D projection, etc., and built a multi-universe starship integrating the main control room, energy supply layer, research and scientific research area, biological experiment base, information exchange area, commercial and trade area and special training ground — — The "Qitian" space star ship carries out education on popular science, experience technology, catering and shopping, and creates an immersive cultural tourism experience scene. There are also digital sports equipment such as "Star Valley Rescue" simulated rock climbing, "Blade Pilot" C919 space simulated driving and "Meteor Trek" space return capsule.

Empowering the sustainable development of creative industries, where is the new productivity cow?

Training Camp Source: Shijingshan Wenlv WeChat WeChat official account

　　Soon after the science fiction park opened, it attracted many science fiction fans to visit the museum. Its subversive creativity, immersive experience, youthful consumption, interactive communication, and sci-fi experience scenes make Shougang Park a "meta-universe" practice exploration platform, an innovative application platform for scientific and technological achievements, and a new landmark for urban rejuvenation and culture.

　　3. London, UK: The deep integration of digitalization and cultural creation.

　　Britain is the first country in the world to put forward the concept of "creative industry". For more than 20 years, the British government has vigorously promoted the development of creative industries, taking creative industries as a "national strategy" and maintaining a high level of concern and high investment. Today, Britain has become the world’s creative center and the world’s leading creative power.

Empowering the sustainable development of creative industries, where is the new productivity cow?

Street graffiti in East London Source: Internet

　　Take East London Science and Technology City as an example, from the poor gathering place and light industrial zone to the gathering center of global science and technology, digital and creative enterprises, it has mainly experienced three development stages: creative talents gathering, strong government blessing and multi-dimensional sustained efforts. In the 1980s, the deindustrialization of the East End of London attracted many artists and young people to start businesses here, and the industrial workshops became art studios, bars and coffee bars. The East End has gradually developed into the most distinctive and artistic neighborhood in London, and a group of cutting-edge designers have begun to move their studios to the East End. The British government issued the national strategy of "Tech City", and at the same time invested 400 million pounds to build the East London Science and Technology City with the silicon island as the core. East London Science and Technology City began to integrate various resources of the city and build an "ecological circle" of scientific and technological innovation industries. In the marketing strategy, the London Science and Technology Advocacy Group (TLA) was established to vigorously promote the Science and Technology City. In addition, the Science and Technology City also sends science and technology ambassadors overseas to promote international cooperation. With the efforts of various forces, East London Science and Technology City has become the fastest growing science and technology hub in Europe.

Empowering the sustainable development of creative industries, where is the new productivity cow?

Talents, funds, policies and enterprises gather in London. Source: London Development Promotion Agency.

　　The case of East London Science and Technology City is only a microcosm of London’s development of creative industries. The British government is not stingy with financial incentives, and has introduced the strategy of "culture is digital" to promote innovation and accelerate the transformation and application of cultural digitalization. For example, in the aspect of digital innovation of heritage collections, the British National Archives launched an online collection working group to launch online resources of digital collections; The new version of "British Digital Strategy" is launched, which emphasizes supporting universities to develop new ideas and technologies and encouraging enterprises to innovate by retaining IP and reducing taxes. In addition, London also provides tax relief policies, takes immersive experience as the key area of creative research and development, advocates circular economy, and forms a creative industry form of "resources-products-renewable resources-renewable products".

Empowering the sustainable development of creative industries, where is the new productivity cow?

Source: Cultural and Creative Review WeChat WeChat official account

　　Today, London, England has achieved its own leap and become a well-deserved global creative center: one of the three largest advertising industry centers in the world, one of the three busiest film production centers in the world and the international design capital, which has concentrated about 90% of music business activities, 70% of film and television activities, more than 85% of fashion designers and more than 30% of design institutions in Britain. The annual output value of London’s creative industries exceeds 21 billion pounds.

　　Looking at the development of new quality productivity, the development of new formats of cultural and creative industries with high concentration and sustainability requires a benign interaction between digital technology and creative content, that is, activating content creativity with scientific research and development and leading technical iteration with novel content.With the blessing of science and technology, traditional culture is innovatively transformed and developed, so that more people love traditional culture, thus enhancing cultural identity and cohesion. Excellent cultural products can also become representatives of the national image, showing the country’s cultural heritage and innovation ability to the world.

　　Looking forward to the future, the sustainable development of new quality productivity in creative industries deserves our more attention. This requires the joint efforts of all walks of life from the bottom up in industrial policy, enterprise management and talent cultivation, combining technology research and development with humanistic spirit, strengthening industry collaboration and international exchanges and cooperation through increasingly mature new quality productivity, creating more innovative and sustainable products and services, and injecting sustainable vitality into the prosperity and development of global cultural industries.

　　Reference link

　　1.https://mp.weixin.qq.com/s/RYI2PXzcJCCxTW_Dfsmt9g

　　2.https://mp.weixin.qq.com/s/hMu3I9mk65lF30Ld6Q_tuw

　　3.https://baijiahao.baidu.com/s? id=1793278319851858343&wfr=spider&for=pc

　　4.http://m.xinhuanet.com/ah/2018-12/25/c_1123897137.htm

Douban scored ＂Love Myth＂, but could not create the box office myth of dialect movies？

From the lack of attention to the release, to the Douban score jumping from 8.1 to 8.3, Love Myth was listed as a high-scoring surprise by many netizens at the end of 2021. As a film in Shanghai dialect, Love Myth not only won the appreciation of Shanghai dialect from the audience in Shanghai, but also was criticized by many audiences in other parts of the country. Dialect blessing makes the film and television creation realistic, and at the same time shows the regional culture, but we should also reflect on the phenomenon of popularization and abuse of dialect films themselves.

author　| Guo Xuemei (author group of cultural industry review, researcher of Sanchuan Huiwen Tourism Research Institute)

read and edit　| Min Lu (Assistant Research Fellow, Sanchuan Huiwen Tourism Research Institute)

edit　| Peninsula

source　| Cultural Industry Review

On Christmas Eve, the "Love Myth", which is based on the Magic Capital Shanghai, was released, which began to arouse heated discussion among netizens.On the one hand, it is the rise of female consciousness, on the other hand, it is the satisfaction of the desire that Shanghai dialect has not been fully interpreted for a long time.

　

Up to now, the film has been inDouban scored 8.3 points.. According to the data of Lighthouse Professional Edition, "Love Myth" also won the box office champion on the opening day of Christmas file in 2021.The total box office was 173 million(still rising).

　

As a film that almost truly presents Shanghai’s worldly wisdom, Love Myth is also properly combined with modern elements. If we go back, in fact, as early as many years ago, Shanghai-language movies such as Stock Craze, Flowers on the Sea and Romantic Death History also attracted people’s attention to Shanghai.However, this time, it is the rare pure Shanghai dialect that inspires more discussion.

　

△ Taobao Film’s "Love Myth" front row comments

The "Golden Age" of Dialect Films

In fact, the phenomenon of abandoning Mandarin and choosing dialects to show movie lines has been prosperous in recent years. Through incomplete statistics, Cultural Industry Review (ID: whcypl) found that there are at least 17 dialects that have appeared in film creation. Apart from those listed in the table, these 17 dialects also include Cantonese movies and Shanghai movies represented by Love Myth.

　

The development of dialect movies is booming, and it has even become a topic that people talk about. There are some basic laws behind its development.

　

Regional characteristics of directors

　

The appearance of many dialect films is often closely related to the directors.In particular, some dialects that are lack of cognition among the public. Pema Tseden, who was born in Tibetan Autonomous Prefecture, and Bi Gan, who was born in Kaili City, Guizhou Province, successfully entered people’s field of vision through directed films with their own local characteristics, such as Pema Tseden’s Tibetan film "Killed a Sheep" and Bi Gan’s Guizhou Kaili dialect film "Roadside Picnic".

　

In fact, going back a little longer, Zhang Yimou’s early film story of qiu ju, and the series of acclaimed films by section chief Jia Zhangke, Xiaowu and Destiny, all used their hometown dialect.

　

On the one hand, it is convenient for the director to express his own theme in detail, and at the same time, it also establishes the director’s personal aesthetic style through the continuous introduction of dialect films, thus creating a "brand" feature.

　

Take "dialect" as a selling point

　

In addition to the director’s own regional characteristics,Nowadays, the "dialect version" has also successfully become an influential factor that people are very concerned about when watching movies.. For example, the interpretation of Sichuan dialect in well-known movies such as Let the Bullets Fly and Nobody is the biggest addition to the comedy effect of the whole movie, which is also an important element that people are keen to discuss these movies.

　

For example, the two films "Lion Boy" and "Hug You Through the Winter", which have been shown recently, are more prominent in the promotion and marketing of the "dialect version". After watching the Mandarin version of the movie, people’s interest in experiencing the original dialect movies was stimulated, which to some extent increased the popularity of the movie on the Internet again.

　

Dialect is favored and valued in film production, which seems to be a natural thing for directors and filmmakers to create and promote, but it actually affects the attention paid to dialect in the film and television industry as a whole, such as whether the actors have enough lines (Ren Suxi, a native of Zhongshan, in Nobody) and the regionality of the actors (almost all the leading actors in Love Myth are from Shanghai).

The Unique Charm of Dialect Films

The use of dialect is loved in film creation, not only because of its own external bonus, but also because of its important role in the authenticity of film plot and the restoration of regional style.

　

Market of film and television creationtaste

　

Yang Haiying, a professor at Beijing Film Academy, once said, "Why do some movies use Henan dialect and Shanxi dialect instead of Mandarin? I think it is mainly to show different living conditions. " For example, Yinan Diao’s The Party at South Station added Wuhan-specific slang to the dialogue, such as "Disobeying Zhou" (unconvinced), "Poor Fire" (immoral, indecent, etc.), Bi Gan’s "Roadside Picnic" read poems in Kaili dialect, and "flowers of war" used the soft language of Wu Nong from gone with the wind, all of which set off the living conditions of movie characters.

　

△ Show the real scene of Wuhan in "The Party at South Station"

　

At the same time, in movies, dialogue is an important means to promote the plot, andDialect can make the plot closer to the real face of a region and let the audience feel the unique fireworks..

　

In the most systematic Cantonese movies of "Dialect+Region", the use of dialects has reached perfection. Through the expression of Cantonese vocabulary and tone, the urban charm of Hong Kong and other regions is accurately conveyed. These auditory elements are not only restoring the social features, but also allowing the audience to experience the scenes in the film across time and space.

　

△ "Over Spring" shows urban differences through the protagonist Pepe’s wandering in Hong Kong and Shenzhen and dialect switching.

　

Proximity of regional culture

　

Dialect features cater to two kinds of people’s psychology of watching movies in the transmission of regional culture:One is a fellow countryman, and the other is a foreigner.

　

The psychology of "fellow villagers" in watching movies is reflected in the fact that the audience in dialect areas will have a natural sense of cultural identity with the local dialect films.For example, the movie "Love Myth", according to the data of Lighthouse Professional Edition, the box office proportion in Shanghai is the highest in all cities in China, whether it is on the day of release or on New Year’s Day holiday, and there is a tendency to continue to widen the gap. This cultural identity based on dialect will make the audience have a special sense of intimacy in the process of watching movies. If the actors are very brilliant in dialect expression, it will increase people’s surprises.

　

△ Relevant data of "Love Myth" on the release day and New Year’s Day holiday

　

Another kind of "stranger" psychology of watching movies is reflected in the fact that audiences in non-dialect areas often show great interest in dialect movies that they rarely dabble in, which makes dialect movies popular in other dialect areas.For example, highly comicNortheast dialect and Sichuan dialectEven though many viewers don’t understand the movie, some funny dialects are widely imitated.

　

Under the influence of these two kinds of psychology, dialect films that seem to be limited in audience can also be tried by a large number of audiences in the early stage of release, and in the audience response of excellent production and good reputation, dialect films can also receive more attention and bring big sales at the box office.

Distinction and abuse behind the popularity of dialect movies

While dialect films have gradually become an important creative form in the film and television industry, they have unconsciously amplified the limitations of dialect films and the abuse of dialects.

　

The barrier of popular consumption of dialects

　

On the one hand, dialect movies have their own viewing threshold.Especially in the dialect like Shanghai dialect, where the understanding level is set, the audience can only know the actors’ dialogue by watching the subtitles. However, due to excessive attention to the understanding of the language, the audience will inevitably reduce their experience of other elements in the movie, resulting in a broken sense of watching.

　

At the same time, some terriers with regional characteristics often appear in dialects.For example, in the comment area of Douban’s "Love Myth", some netizens share the Shanghai connotation of "I raise Nong"-at most, it is a love story, and most of the time it is a deliberate attempt to be brave and empty inside. It can be seen from this that the expression habits behind dialects also set a threshold for the audience to understand.

　

On the other hand, because commercial films should be geared to the masses, a large dialect or even a whole dialect will reduce the appeal brought by dialect characteristics.In fact, for the easy-to-understand Dongbei dialect and Sichuan dialect, dialects are an addition, but some difficult dialects will be counterproductive, which may also be the gap between Nobody and Love Myth. One is a dark horse at the box office, and the other can only party in circles.

　

Abuse of dialect labels

　

In the outstanding performance of dialect films,Due to the excessive exertion of some films, dialects themselves have evolved into a critical point.For example, some netizens once said that the dialect in The Man Caught by Light did not bring a sense of substitution and resonance, but more discomfort.

　

From this, we can think about whether all films are suitable for combination with dialects; Whether the fundamental use of dialects has been ignored by the creators when there are a lot of dialect films and even a hodgepodge of dialects appears in a film; How to creatively use dialects instead of simply piling up dialect elements is also a problem to be faced in the future.

　

△ "Love Myth" related Douban comments

　

Compared with plot processing and story integrity, dialect is not the whole feeling of the audience for a film, nor is it the core element that people abandon to watch, but well-received dialect films are often willing to pay attention to dialect dialogue, such as the outstanding performance of Love Myth. When the audience feels the intention of the production team, in fact, dialect films can escape the imprisonment of regional circles, and even minority films can have excellent results.

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"Love Myth" has attracted great attention to dialect films such as Shanghai dialect films, and also made many audiences feel more comprehensive about dialect films.In the increasingly vigorous development of dialect film creation, we are also expected to see the contribution of film dialects to the spread of regional culture.

　

When the aesthetic feeling of language is not limited to the sameness of Putonghua, the dialect with real and original ecology brings us new artistic experience, which may also be a symbol that movies come from life and return to life.

　

reference data

[1] Ji Bingjie. On the change of artistic effect of current dialect films. Audio-visual.2018, (09): 52-53

[2] Cao Zhong, peng bo. The performance paradigm of dialect narrative in the film "Nobody". Satellite TV and Broadband Multimedia. 2019,(21): 97-98


　　

Details, the coolness of the living room can’t be ignored by the coffee table ~

-Creating a sense of coolness in summer, living room, coffee table, floral design-

Recently, a series of green popular science videos of "Lvxin Station" launched by Pudong New Area Greening Committee Office and Pudong New Area Greening Management Affairs Center were launched.

Today, let’s take a look at how to create a living room coffee table floral.

"Living room coffee table floral"

A pot of living room coffee table flowers

Bring infinite elegance to summer

The living room is the place where friends get together most often, and the tea table flowers in the living room can also reflect the taste and attitude of the host.

▎ Living room coffee table flowers-material preparation

-Creating a sense of coolness in summer, living room, coffee table, flowers and materials-

Flower materials: water lily, green carnation, copper money grass, green pearl and Brazilian leaves.

Tool accessories: flower paste, flower paste knife, gardening scissors.

Flower: glass jar.

▎ Selection of flower-flower material flower device for living room coffee table

-Selection of living room flowers and water lilies-

Water lilies, which are common in summer, are chosen as the flower material, which means "good luck" and elegance and refinement.

-Selection of living room flowers and glass jars-

On the flowerpot, the glass jar standing at home is used, and its clear texture gives people a cool feeling.

-Creating a sense of coolness in summer, living room coffee table, floral design and water lily maintenance-

▎ Living room coffee table flower-water lily maintenance

Water lily is one of the common flower materials in summer. The bought water lily is closed due to lack of water, so it should be maintained first.

-Creating a sense of coolness in summer, living room, coffee table, floral arrangement and root pruning-

Pruning: cut the bottom of the flower stem of the water lily flat.

-Creating a sense of coolness in summer, living room, coffee table, floral design, and sepals stripping-

Stripping sepals: It is difficult for water lilies wrapped by sepals to open naturally. You should strip all the green calyx petals, or leave one or two water lilies in the bouquet according to your personal preference.

-Creating a sense of coolness in summer, living room, coffee table, floral arrangement and stem irrigation-

-Creating a sense of coolness in summer, living room, coffee table, floral arrangement and stem irrigation-

Stem irrigation: Turn the water lily upside down and pour water into the flower stem. Because the flower stem of the water lily is soft and smooth, it is difficult to absorb water. To make the flower head absorb water, block the flower stem filled with water by hand and quickly invert it into a high vase in deep water.

▎ Flower material of living room coffee table-flower mud modeling and package beautification

-Create a sense of coolness in summer. Flower on the coffee table in the living room. Cut the flower paste-

Cutting flower mud: Invert the glass jar above the flower mud and cut it along the inner edge of the mark with a flower mud knife.

-Creating a sense of coolness in summer, making flowers and purees on the living room coffee table-

Soak the flower mud: put the flower mud vertically into a plastic basin and immerse it naturally for about 2 minutes.

-Creating a sense of coolness in summer, living room coffee table flowers, wrapped Brazilian leaves-

-Creating a sense of coolness in summer, living room coffee table flowers, wrapped flowers and mud-

Wrap Brazilian leaves: remove the stems and veins protruding from the back of Brazilian leaves and wrap the flower mud.

The beautification of the flower mud is completed.

▎ Living room coffee table flower-making

-Create a sense of coolness in summer. Flower selection in the living room coffee table-

Three water lilies with different degrees of openness were selected to insert the main flowers, one full-open, one half-open and one bud-shaped.

-Create a sense of coolness in summer, set the height of the living room coffee table flowers-

Insertion of main flower: the retention length of the first flower material is the height of flower device+1.5 to 2 times the width of flower device+the height inserted into flower mud (about 2 cm). See the video for the measurement method.

-Create a sense of coolness in summer. Flower cutting in the living room coffee table-

After the height of the flower material is set, it can be cut as needed.

-Create a sense of coolness in summer. Flower on the coffee table in the living room. The first flower is inserted-

The first flower is inserted at the back of the center of the flower paste.

-Create a sense of coolness in summer. Flower on the coffee table in the living room. The second flower is inserted-

In the second bud state, the height is about 2/ 3 of that of the first branch.

-Create a sense of coolness in summer. The third flower is inserted in the coffee table of the living room-

The fully open state of the third branch is about 1/ 3 of that of the first branch.

-Creating a sense of coolness in summer, living room coffee table flowers and lower space filling-

Lower space filling: use green carnation to fill the lower part of the work.

-Creating a sense of coolness in summer, living room coffee table flowers, flower mending-

Patching flowers: Cut some leaves of copper grass, insert them among green carnations, and then take 2-3 green beads to make a jumping supplement below to increase the sense of vitality.

-Creating a sense of coolness in summer, living room coffee table flowers and water-

Add water: Finally, add enough water to the glass jar.

-Creating a sense of coolness in summer, living room coffee table flowers and works display-

That’s all for sharing the making of coffee table flowers in the living room. Try to make them and "rejuvenate" your living room!

Original title: "Details, the coolness of the living room can’t be ignored."

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COVID-19 vaccination, what you want to know is here (1)

Vaccination is the most effective means to prevent and control infectious diseases. According to the latest information of the State Council Joint Prevention and Control Mechanism on 23rd, the vaccination amount of COVID-19 vaccine in China has exceeded 100 million at home and abroad, which will build the biggest immune barrier.

Huangpu District has completed 124,000 doses of COVID-19 vaccination since the new crown vaccination, and is now further promoting the national vaccination. Eligible residents in the area can go to the designated inoculation point for free COVID-19 vaccination.

At the inoculation site, we often meet the recipients who don’t understand the relevant terms in the inoculation consent form clearly. In order to make people understand more about the specific situation that COVID-19 can be vaccinated, suspend vaccination or not recommend vaccination, we will present the common problems and answer your questions, so that those who are willing to vaccinate in COVID-19 can understand the relevant issues more clearly and make preparations in advance.

+ + + +

Can the elderly be vaccinated?

From March 25th, 2021, the city started the registration and appointment vaccination of COVID-19 vaccine for people aged 60 and above. Community residents (China nationality) aged 60-75 years old who are healthy and have no contraindications in this city can make an appointment for vaccination through the registration of the whole community system and go to the designated community inoculation point for vaccination. For on-the-job personnel aged 60-75, they can also choose to participate in the vaccination organized by the whole organization of the unit and vaccinate at large temporary vaccination sites. Residents aged 76 and above will start vaccination in due course according to the vaccination schedule.

Can foreigners be vaccinated?

From March 29th, 2021, according to the principle of "informed, voluntary, at one’s own expense and at one’s own risk", the city will include the school-age population among foreigners in Shanghai in the range of domestic vaccine inoculation (listing stage).

Foreigners who voluntarily vaccinate in Shanghai can make an APPointment to register for vaccination online through the "Healthy Cloud" app. Foreigners who have participated in our social security medical insurance enjoy the same treatment as other China citizens. Foreigners who are not insured shall be vaccinated at their own expense, and the cost is 100 yuan/dose.

What kind of vaccine are we vaccinated against?

At present, COVID-19 vaccines are used in this city, including Covid-19 inactivated vaccine produced by Wuhan Institute of Biological Products, Beijing Institute of Biological Products and Beijing Kexing Zhongwei Biotechnology Co., Ltd., which belongs to China Biology of Sinopharm Group. At present, COVID-19 vaccines with other R&D technical routes are being marketed one after another, and the vaccine products to be supplied later will be adjusted in time according to the market situation of vaccines.

How many shots is COVID-19 vaccinated?

At present, the recommended basic immunization program of inactivated vaccine in Covid-19 is 2 shots with an interval of at least 21 days, and the inoculation site is deltoid muscle of upper arm. Inoculation procedures and inoculation sites of different vaccine products are different, which shall be subject to the vaccine product specifications.

What are the conditions for the vaccination target to suspend the vaccination of COVID-19 vaccine?

It is suggested to suspend the vaccination of COVID-19 vaccine in the following circumstances:

① those who are allergic to any component in the vaccine;

② Severe allergic reaction (such as acute allergic reaction, angioneurotic edema, dyspnea, etc.) occurred before vaccination;

③ People suffering from acute diseases, severe chronic diseases, acute onset of chronic diseases and fever;

④ Pregnant and lactating women;

⑤ Patients with uncontrolled epilepsy and other progressive nervous system diseases have a history of Guillain-Barre syndrome;

Subject to the specific vaccine product instructions or instructions for use.

Can chronic diseases such as hypertension, hyperlipidemia and hyperglycemia and chronic gastritis be vaccinated with COVID-19 vaccine?

If chronic diseases are in a stable state of control through treatment, such as blood sugar, blood pressure and blood lipid, and chronic gastritis is in a non-attack stage, they can be vaccinated; If the relevant indicators are unstable, or in an acute attack period, it is recommended to suspend vaccination.

It is suggested to suspend vaccination for those with abnormal liver and kidney function.

Can people with allergic constitution or allergic skin diseases (such as urticaria) be vaccinated with COVID-19 vaccine?

Serious allergic reactions (such as acute allergic reactions, angioneurotic edema, dyspnea, etc.) have occurred in the past or are in the onset of allergic diseases. It is recommended to suspend vaccination.

Original title: "Vaccination in COVID-19, what you want to know is here (1)"

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Comments on the management of the board of directors of Novartis in the first half of 2022

() The business review of the Board of Directors in the first half of 2022 is as follows:

　　I. Description of the industry and main business of the company during the reporting period.

　　(I) The industry of the company during the reporting period.

　　1. Development trend of global pharmaceutical industry

　　According to the report "The Global Use of Medicine 2022 Outlook to 2026" released by IQ via in December 2021, the global pharmaceutical market will reach 1.8 trillion US dollars in 2026, with a compound growth rate of about 3-6% from 2022 to 2026.

　　2. Development trend of domestic pharmaceutical industry

　　The aging population in China is on the rise year by year, and by 2050, the aging population in China will reach one third of the total population. With the aging of the population, the demand for medicine market in China has increased sharply. At the same time, the government of China proposed to coordinate the promotion of medical reform and the release of medical policies to benefit the people one after another, which promoted the growth of the medical market. In the future, the pharmaceutical industry in China will face a reshuffle, and the market system will be constantly standardized and improved in the adjustment of policies to enhance market supply. With the expiration of a large number of patents of "heavy drugs" around the world, pharmaceutical enterprises in China will have great development opportunities.

　　3. The pattern and development trend of contract customization R&D and production (CDMO) business

　　The market capacity of global pharmaceutical customized R&D and production industry is growing rapidly. In recent years, in order to reduce the R&D cost of new drugs, improve the R&D efficiency, shorten the R&D marketing cycle and reduce the post-marketing drug production cost, the penetration rate of customized pharmaceutical R&D production services has been increasing continuously. According to Frost&Sullivan’s data, in terms of CMO/CDMO, the proportion of global pharmaceutical companies’ R&D investment in CMO/CDMO in 2017 was 36.04%, and it is expected to increase to 52.22% by 2022. The continuous growth of global pharmaceutical R&D investment and the increasing penetration rate of pharmaceutical customized services will promote the continuous growth of market demand in the pharmaceutical customized services industry. CMO/CDMO industry not only benefits from the market demand brought by the continuous growth of R&D investment in the pharmaceutical industry, but also can share the growth dividend after the listing of innovative drugs, and the market space continues to grow. According to Frost&Sullivan data, the global small molecule CDMO/CMO market scale has increased from 42.3 billion US dollars in 2014 to 64.6 billion US dollars in 2018, with an average compound annual growth rate of 11.2%. It is expected to keep growing at an average compound annual growth rate of 10.7% and reach 107.2 billion US dollars by 2023.

　　4. Development trend of characteristic API industry

　　In November 2021, the National Development and Reform Commission and the Ministry of Industry and Information Technology jointly issued the Notice on the Implementation Plan for Promoting the High-quality Development of the API Industry. This notice was based on the Guiding Opinions on Promoting the Green Development of the API Industry issued by the Ministry of Industry and Information Technology in December 2019 with the Health and Health Commission, the Ministry of Ecology and Environment, National Medical Products Administration and other ministries and commissions, and further put forward a more systematic guiding direction for the production of APIs in China, including "adjusting the industrial structure of APIs". "Optimizing the layout of API industry", "accelerating technological innovation and application", "promoting green production standards" and "promoting the construction of centralized production bases" indicate the future trend of China’s characteristic API industry led by policies.

　　According to "Active pharmaceutical ingredients (API) market-growth, trends, and forecast (2020-2025)" published by Mordor Intelligence, the global API market has reached 165.7 billion US dollars in 2018, and it is estimated that the market size will reach 236.7 billion US dollars in 2024, with a compound annual growth rate of 6.12%. From the perspective of API supply areas, it is mainly concentrated in China, India, Italy, the United States, Europe and other regions. Western Europe, represented by Italy, was once the largest country in the world.

　　Material and medicine production base. According to Evaluate Pharma, between 2020 and 2024, a total of nearly $160 billion of patented drugs will expire. According to the price of generic drugs is about 10%-20% of patented drugs, the replacement space of generic drugs in the past five years is about 16-32 billion US dollars. The expiration of a large number of patented drugs will stimulate the sustained growth of the generic drug market and drive the expansion of the characteristic API market.

　　5. The pattern and development trend of preparation business

　　In recent years, the centralized procurement policy organized by the state has promoted the reform of the preparation industry. In the context of slowing economic growth, aging population, and the gradual decline of per capita income growth and fiscal revenue growth, it is imperative to control medical insurance fees, and purchasing generic drugs with quantity is an important means to control medical insurance fees. Since 2018, in order to improve the utilization rate of medical insurance funds and reduce the unreasonable profiteering of generic drugs and original research drugs that have passed the patent period, the speed of quantity procurement has been accelerating, and it has been promoted routinely. According to the data of previous centralized purchasing published by the National Medical Insurance Bureau, the average price reduction of drugs in the first, second, third, fourth, fifth, sixth and seventh rounds was 52%, 53%, 53%, 52%, 56%, 48% and 48% respectively. In the old drug sales model, the sales expenses accounting for about 40% were almost completely squeezed. The substantial reduction in the price of generic drugs has promoted the increase in drug penetration and led to the increase in sales.

　　With the normalization and institutionalization of centralized procurement in pharmaceutical industry, the company will follow the development of the industry, seize every opportunity to win the bid in centralized procurement and regional alliance, and have more varieties of centralized procurement is the long-term strategy for the company’s development and growth.

　　(II) Main business of the company during the reporting period

　　Minova is a comprehensive international pharmaceutical technology manufacturing enterprise specializing in the research, development, production and sales of characteristic APIs (including intermediates, the same below) and finished drugs. It is one of the top 100 pharmaceutical enterprises, one of the top 100 manufacturing enterprises in Ningbo, and a quality supplier and partner in the international market (ranked in the top 60). It focuses on the integration of CDMO, characteristic APIs and preparations, and its services cover mainstream countries and regions around the world. Its core products cover cardiovascular and central nervous system. The company is one of the enterprises that export the most varieties of raw materials with European characteristics in China.

　　During the reporting period, the company achieved a total operating income of 897 million yuan in half a year, an increase of 29.74% over the same period of last year; The net profit attributable to shareholders of listed companies was 185 million yuan, an increase of 58.71% over the same period of last year; The net profit attributable to shareholders of listed companies after deducting non-operating gains and losses was 171 million yuan, up 74.48% over the same period of last year. The net cash flow generated by the company’s operating activities was 151 million yuan, up 35.29% over the same period of last year.

　　Adhering to the business tenet of "pursuing perfection in product quality, keeping promises in business operation, and advancing with people and enterprises", the company has been deeply involved in its main business for a long time, serving the European and other medical standard markets for 19 years. With strict quality management and EHS management capabilities, solid process development and high-standard large-scale manufacturing capabilities, as well as fine and efficient team fighting capacity, We have established long-term, deep and stable cooperative relations with well-known pharmaceutical enterprises at home and abroad, such as KRKA, MSD (Merck), Servier (Servier), Bayer (Bayer), GEDEON RICHTER (Jirui Pharmaceutical), SANOFI (Sanofi), () and Kaituo Pharmaceutical. The company has formed a high brand international reputation and competitive advantage in CDMO sub-sectors and characteristic API sub-sectors, and gradually established a leading position in domestic and foreign markets.

　　Since its listing in 2017, the company has taken advantage of the capital market, driven by the two-wheel drive of "connotative growth+extensional expansion", consolidated and strengthened the characteristic API business, and firmly deepened the integration strategy of "pharmaceutical intermediates, APIs and preparations" by relying on continuous R&D innovation and business expansion, expanding and extending the upstream intermediates and downstream preparations business, so as to further improve the industrial chain layout and fully expand the integration advantages; At the same time, based on the competitive advantage in the field of characteristic APIs and customer network resources, the company continued to lay out CDMO business, accelerated the creation of a one-stop integrated service platform for CDMO, and provided strong impetus for the company’s subsequent development. With continuous improvement of multi-dimensional strategic layout, the company actively develops and commercializes cutting-edge medical products with CDMO business and preparation integration business as the core, helps the company to "start a second venture" and is committed to making Minova a first-class domestic, internationally renowned and highly competitive international pharmaceutical technology manufacturing enterprise.

Second, the discussion and analysis of the business situation

　　In the first half of 2022, the company has always been based on high-starting planning, high-standard construction, high-level operation and efficient management, and has always adhered to and focused on the specialization, synergy and integration of its main business, achieving steady operation and rapid development.

　　In the first half of 2022, under the background of increasingly severe international political and economic forms, the COVID-19 epidemic occurred repeatedly at home and abroad, and the global economy continued to decline as a whole, the company actively responded to changes in the internal and external environment, made overall plans to promote epidemic prevention and control and business development, actively adapted to the new normal production and operation mode, followed the company’s development strategy and work plan to carry out various production and business operations in an orderly manner, and ensured the stock business.

　　At the same time, we strengthened the development of incremental business, and finally realized the steady growth of operating income, and set up a layout in various business sectors, forming diversified business types and deepened products, laying a more solid foundation for the sustainable development of enterprises.

　　The company has practiced the core values of "taking responsibility bravely and achieving value" with actual operation and development.

　　During the reporting period, the Company’s main business activities were as follows:

　　(A) Strategic layout of new business, CDMO growth can be expected

　　CDMO business is the core driving force of the company’s development. Relying on the existing base, driven by talents leading innovation, the company continuously increased R&D investment, established an independent CDMO process development technology platform, strengthened quality control capability, safety and environmental protection capability and information security capability, optimized project management and production process, and comprehensively shaped CDMO hard core strength.

　　With the signing of the strategic agreement of the international pharmaceutical giant enterprise, the influence of the company’s CDMO international brand has been greatly improved, and the development progress of the company’s major customers has been accelerated. With the continuous development of CDMO business, the company undertakes more and more customer project pipelines. Through the delivery of each project, it realizes the sticky binding with customers, and the customer cooperation continues to deepen. The CDMO business volume will continue to show a trend of double growth. At the same time, as the main target of the company’s CDMO business in the future, small nucleic acid drugs have developed from 0 to 1, and the customized synthesis business of pharmaceutical intermediates in COVID-19 has begun to take shape. It is expected that the CDMO business will become the company’s biggest revenue and profit growth point in 2022 or 2023. During the reporting period, the company completed the complete holding of its subsidiary Xuancheng Menuohua. As the core base of the company’s CDMO business, it will contribute all profits to the company in the future.

　　1. The CDMO business of small molecular intermediates and APIs has made great strides.

　　In the first half of 2022, we adhered to the established strategic transformation policy and vigorously promoted the CDMO business. At present, the company’s CDMO business has established business cooperation with more than 100 outstanding pharmaceutical companies at home and abroad.

　　Since the outbreak of Xinguan epidemic, the company has paid close attention to the research and development progress of COVID-19 drugs at home and abroad, focused on the mainstream technical route, carried out technical reserve work in a planned way, and laid out corresponding production capacity. At present, the company has a number of production processes of key intermediates and APIs of COVID-19 specific drugs, and some of them have been commercialized.

　　2. The small nucleic acid platform is ready to go

　　In 2021, the company took the lead in the field of nucleic acid drugs and gene sequencing. After R&D and development, the company has undertaken the CDMO business of nucleoside intermediates used in small nucleic acid drugs, nucleic acid detection, gene sequencing and other fields, providing raw materials for mainstream products such as nucleic acid detection and gene sequencing at home and abroad. Although the small nucleic acid raw material business is still in its infancy, as one of the main targets of the company’s CDMO business in the future, the company will unswervingly develop according to the established plan and continue to become bigger and stronger.

　　3. Reach a ten-year strategic cooperation with Merck, a large multinational pharmaceutical company, and comprehensively accelerate the construction of CDMO hard core strength.

　　In 2021, the company signed a ten-year CDMO strategic cooperation agreement with Merck, a large multinational pharmaceutical company, in the fields of pet medicine, veterinary medicine and animal health care. By the end of the reporting period, the nine projects in the first phase have been carried out in different stages according to the schedule and will soon be commercialized; A number of projects are being evaluated in the later period, and both sides are committed to continue to explore more projects and more diversified cooperation possibilities. The cooperation project between the company and Merck will become a new growth point for the company’s performance contribution after it is transferred to the stage of commercial mass production.

　　Merck is a global health care company, mainly engaged in prescription drugs, vaccines, biological products and animal health products, providing innovative medical solutions for more than 140 countries and regions. This strategic cooperation reflects Merck’s full recognition of the company’s research and development technology, production and quality in the field of APIs, which has a far-reaching and significant impact on the company’s development, especially the development of CDMO’s new business. The company will take this cooperation as an opportunity to strengthen the interconnection with Merck in order to form more broad consensus and promote the company to reach more fields and deeper future cooperation with Merck. At the same time, the company will continue to improve its R&D technical capabilities, project management capabilities and delivery capabilities, accelerate the strategic layout of CDMO business, and further build the company’s international competitiveness in the CDMO field.

　　4. Acquisition of 49% equity of Xuancheng Menuohua to further improve the strength of CDMO software and hardware.

　　During the reporting period, in order to speed up the layout and improve the strength of CDMO software and hardware, the company completed the acquisition of 49% equity of Xuancheng Meinuohua held by Meinuohua Ruihe Fund. So far, the company holds 100% equity of Xuancheng Meinuohua.

　　Xuancheng Minova is an important service platform for the company’s CDMO business, and multi-functional workshops supporting CDMO business have been put into production one after another. It has a complete multi-functional GMP workshop and safety and environmental protection facilities. The production equipment adopts the domestic leading closed, automatic and pipeline design, and the equipment is flexibly connected to achieve the purpose of multi-function. The reaction types cover many kinds of chemical reactions, including complex reactions such as format, fluorination, cyanidation, hydrogenation, oxidation, azide, etc. The hydrogenation reaction pressure is up to 9.9MPa, and a number of standardized and multi-functional fine baking packages are built, and the scale can range from kg to 100 kg. The production process is controlled by DCS, and the production data is recorded electronically and kept permanently to ensure the integrity of the production data. High-risk reactions are escorted by SIS system, which can provide sustainable, flexible and reliable CDMO services in line with international GMP standards for global customers. Adequate wastewater and solid waste treatment capacity and advanced RTO and carbon fiber adsorption waste gas treatment equipment can also provide sustainable services to escort.

　　(2) Promote the development strategy of "integration of intermediates, APIs and preparations" and accelerate the pace of strategic transformation.

　　In the first half of 2022, under the background of generic drug collection policy, the company’s preparation sector developed strongly. The company takes the integration of "intermediates, APIs and preparations" as the strategy, and makes use of the advantages of the company’s API industrial chain to concentrate on developing preparations of superior varieties of APIs to help the company develop. The company actively implemented the development strategy of "technology transfer+independent declaration+domestic MAH cooperation", deepened the vertical integration and coordination of the whole industrial chain, enhanced the company’s comprehensive competitive strength, grasped the opportunity of rapid commercialization and heavy volume brought by the national centralized purchasing policy, and achieved phased results.

　　1. The centralized procurement was successfully renewed, and the preparation business continued to increase in volume.

　　In the first half of 2022, the company’s perindopril tert-butylamine tablets realized the renewal of the drug alliance procurement of thirteen provinces (autonomous regions, municipalities and corps) of the new corps of Yujin, Menge, Hubei, Hunan, Guiqiong, Chongqing and Guiqingning and the centralized drug procurement in Hebei Province. The delivery of pregabalin capsules, losartan potassium tablets, atorvastatin calcium tablets and lisinopril tablets which won the bid in 2021 is in normal progress. Under the background that the policy of purchasing with quantity weakens sales promotion, winning the bid for centralized purchasing of drugs can not only bring new profit growth points for the company, improve market share and brand influence of the company, but also promote the pace of preparation transformation of the company.

　　2. Accelerate the pace of self-research and registration of cooperative preparation varieties, and many varieties will be approved for listing one after another.

　　During the reporting period, the company’s apixaban tablets and valsartan tablets were approved for listing, and isoniazid tablets passed the consistency evaluation. It is expected that 2-3 varieties will be approved in the second half of the year. As of the reporting date, the company has accumulated 10 preparation products approved for listing in China.

　　During the reporting period, the company newly established 11 varieties, and 3-5 projects are about to enter the BE stage. Five projects, including Propofovir Fumarate Tablets, Engelje Tablets and Dapagliflozin Tablets, have passed the formal BE test, and 10 varieties are under CDE approval. It is expected that 8-10 varieties will be submitted to CDE for review in the second half of the year. At present, the company has more than 20 projects under research.

　　3. Layout the "heavy drugs" with patent expiration in advance, and the company has a huge development opportunity.

　　In recent years, the drugs whose patents have expired mainly focus on cardiovascular system, hypoglycemic drugs, antineoplastic drugs, nervous system drugs, mental disorders drugs, digestive system drugs and other therapeutic fields. At present, the company has laid out products such as sitagliptin metformin tablets, Aggliptin benzoate tablets, Dapagliflozin tablets, Vonolasone fumarate tablets, Shakubatrivalsartan sodium tablets, Ibtinib capsules and so on. Among them, the company cooperates with strategic customers KRKA raw materials and preparations, and rivaroxaban and dabigatran axetil have been listed for the first time in Europe and have been commercialized.

　　(3) Continuous cultivation and long-term layout of characteristic APIs

　　Characteristic APIs and intermediates are the traditional core business of the company. During the reporting period, the company continued to strengthen market development, deepen cooperation with strategic customers, expand cooperation scope, and strive to develop and cultivate new customers at home and abroad, constantly optimizing customer structure and product structure.

　　1. Continuously optimize the customer structure and cultivate key customers.

　　During the reporting period, the company continuously strengthened its contact with international head original research companies, and added supplier certification of two original research companies. For existing strategic customers, the company has continuously explored the depth of cooperation and expanded the scope of cooperation. The cooperation with Sylvia has expanded from single product and upstream intermediates to advanced intermediates and API, and two new projects have made progress in stages. The company further strengthened its strategic cooperation and deep binding with KRKA. Based on years of cooperation in the European market, the two sides jointly tapped the market potential of China, and added seven new project cooperation on the basis of the original cooperation varieties.

　　In addition, many core varieties of the company entered the project stage with many global multinational pharmaceutical giants, and carried out substantive cooperation and communication with many top 100 domestic pharmaceutical companies, especially Qilu Pharmaceutical, Zhengda Tianqing, Yangzijiang, (), etc., laying a solid foundation for business growth in the next 2-3 years.

　　During the reporting period, by giving full play to its comprehensive competitive advantages and resisting the pressure of epidemic situation, the company actively strived for incremental growth and overcame various difficulties. The company actively explored channels and cultivated new customers, especially in South America, Japan and South Korea, and made breakthrough progress.

　　2. Implement multi-category and multi-market routes of APIs, and accelerate the development and registration of new products.

　　During the reporting period, the company accelerated the development and registration of new products, so as to expand the access of existing API products to China market and European and American standardized markets. At present, there are 54 varieties of APIs under research, of which 20 varieties have been converted to production, 6 varieties have been submitted for overseas market registration and certification, 1 variety has been submitted for domestic CDE registration, and 1 variety has been submitted for domestic veterinary drug product approval number application.

　　During the reporting period, one variety of losartan potassium obtained the EU CEP certificate; Valsartan, clopidogrel bisulfate crystal form II, mirtazapine and rivaroxaban have passed the domestic review and approval. As of the date of this report, another API of esmomeprazole magnesium has passed the domestic review and approval.

　　3. Strictly abide by the quality lifeline and continue to maintain excellent compliance records.

　　In recent years, with the continuous introduction and improvement of a series of new regulations and systems of domestic and foreign regulatory agencies, the requirements for all aspects of drugs from research and development, production to listing have become stricter, and the company has also raised its own requirements for quality management and risk management. The company absorbs advanced ideas and experiences from all parties, tamps down the quality management system, pays close attention to detail management, traceability management and on-site management, and continuously strengthens the quality defense line.

　　The company continuously optimizes the GMP system with high requirements, high standards and high quality work norms, and constantly consolidates the foundation of quality management. During the reporting period, the group company successfully passed 9 domestic official inspections and 21 customer audits, including well-known enterprises at home and abroad such as Novartis Pharmaceutical, Merck and Boehringer Ingelheim. All previous audits have passed smoothly, and the company’s quality system has been highly recognized by officials and customers.

　　At the same time, the company adheres to the enterprise purpose of "pursuing perfection in product quality", continuously improves the quality management system in line with international standards, improves the quality awareness of all staff, and continuously strengthens the study of laws and regulations. The company continued to carry out quality month activities, actively promoted the construction of quality culture and informatization, raised the awareness of all staff to ensure the company’s cGMP management level to a higher level.

　　(D) Continue to build and enhance the capacity of scale, and the harvest period of high-quality production capacity is approaching gradually.

　　By the end of the reporting period, the main body of the first phase of Anhui Minova’s "Technical Transformation Project with an annual output of 400 tons of APIs" has been completely completed, and the installation of workshop equipment has been basically completed, and some workshops are ready for trial production; Zhejiang Meinuohua’s "annual output of 520 tons of APIs" phase I project has all been completed, and some workshops have completed electromechanical installation; The fundraising project "Construction Project of Export Solid Preparations with an Annual Output of 3 billion Tablets (Granules)" was completed during the reporting period and is ready for trial production; The convertible bond fundraising project "high-end preparation project" is under construction, and some of the buildings have been capped.

　　All production bases are coordinated and complementary, and CDMO business and API business are distributed in many places. By building the competitiveness of large-scale production capacity, taking high-quality scarce production capacity as a springboard for development, we will seize the opportunity of rapid development of the industry, seize market share, improve the company’s development speed and lay the foundation for future growth.

　　Major changes in the company’s operation during the reporting period, as well as matters that have a significant impact on the company’s operation during the reporting period and are expected to have a significant impact in the future.

Third, possible risks

　　1. Risk of product quality control: Most of the company’s products are raw materials used to produce preparations, and quality management is particularly important. The company’s product quality is affected by many factors due to its long production process and complicated technology. If there are occasional factors in the process of purchasing raw materials, storing and transporting products, it may cause physical and chemical reactions of products and lead to product quality problems.

　　Risk control measures: the company will always implement the concept of "quality is the lifeline of the enterprise", start from the details, strengthen process management, improve management level and quality awareness, strengthen internal inspection, and implement international quality standards with high standards.

　　2. Safety production and environmental protection risks: flammable, explosive and toxic substances need to be used in the production process of the company. Improper operation or aging and disrepair of equipment may lead to safety accidents. The company’s industry is an industry with high requirements of national environmental protection supervision, and the relevant state departments have always attached great importance to the environmental protection management of the pharmaceutical industry. With the enforcement of the Discharge Standard for Water Pollutants in Pharmaceutical Industry, the environmental protection pressure of pharmaceutical manufacturing enterprises involved in fermentation, chemical synthesis, extraction, traditional Chinese medicine, bioengineering and mixed preparations has increased.

　　Risk control measures: Each production base of the company has established an EHS management system based on international standard capabilities, always increased the investment in safety and environmental protection facilities, adhered to prevention, improved the safety management and three wastes treatment capabilities, and effectively reduced the safety, environmental protection and safety production risks.

　　3. Market competition risk: API business may be affected by factors such as capacity certification cycle, technology transfer, technology redevelopment, etc. As domestic and foreign competitors participate in market competition, the company will face the risk of market competition.

　　Risk control measures: The company deepens the cooperation mode with existing customers, actively expands new customers and markets, and actively develops new varieties to continuously enhance its own market competitiveness.

　　4. Risk of exchange rate fluctuation: overseas markets account for a high proportion of the company’s operating income, and most of them are priced and settled in foreign currencies such as US dollars, while the company’s expenses are mainly paid in RMB. If the exchange rate of RMB against the US dollar and other foreign currencies continues to rise, even if the company’s foreign currency sales price remains unchanged, the converted RMB sales revenue will decline, and vice versa. Therefore, exchange rate fluctuations directly affect the level of profitability.

　　Risk control measures: the company relies on the advantages of product quality, technology and cost to provide quality services to customers, expand the market, enhance customer trust and satisfaction, and increase market share and bargaining power of product sales. At the same time, the company chose the right time to lock the forward exchange rate of some US dollar assets, and moderately increased foreign currency loans with low interest rates to hedge the risk of the decline of the US dollar exchange rate of unilateral US dollar assets.

　　5. Risk of product R&D not meeting expectations: The product R&D in the pharmaceutical industry has the characteristics of high technical difficulty, large capital investment and long approval period. Therefore, in the process of continuous investment in R&D projects of the company, there may be the risk of product R&D not meeting expectations.

　　Risk control measures: the company continues to invest in R&D, increase the introduction of excellent R&D talents, and improve the success rate of R&D projects.

　　6. Risk of raw material supply and price increase: The company has established a stable cooperative relationship with major suppliers. However, in case of force majeure factors such as natural disasters, or the domestic safety and environmental protection requirements are becoming stricter, the production capacity of some suppliers is limited, and raw materials may be in short supply, price increase or raw materials cannot meet the quality standards required by the company’s production, which may affect the profitability of related products of the company to a certain extent.

　　Risk control measures: Facing the risks of raw material supply and rising prices, the company will strengthen the management of supply chain, sign strategic cooperation agreements and increase binding terms of price adjustment.

　　7. Depreciation risk of fixed assets: With the commissioning of the company’s reconstruction and expansion projects, the projects under construction will be converted into fixed assets one after another, which will lead to the increase of depreciation expenses of fixed assets. If the company can’t reach the expected level due to the depressed industry environment in the future, the new benefits brought by the use of fixed assets may not make up for the amount of depreciation.

　　Risk control measures: The company will actively expand new customers and new products, and through the release of new production capacity, continuously improve customer service capabilities and increase operating income.

Iv. analysis of core competitiveness during the reporting period

　　The company has been deeply involved in the pharmaceutical industry for many years, and has accumulated rich experience in industrial investment layout, industrial transformation and upgrading, industrial resource integration and other aspects, forming a systematic core competitiveness with technology research and development, quality control, EHS management, customer service and talent team.

　　(A) the advantages of integrated pharmaceutical industry chain

　　Through years of industrial layout, the company has a complete industrial chain of "pharmaceutical intermediates, raw materials and preparations". The core products of the company, such as valsartan, losartan, clopidogrel, perindopril, rosuvastatin calcium, atorvastatin calcium and pregabalin, have formed a commercial R&D, production and sales system of the whole industrial chain. The layout of intermediates and APIs ensures the high standard and consistency of preparation quality from the source, ensures the stability of key raw materials supply, and brings strong quality advantages and cost advantages. The company will continue to promote the optimization and upgrading of the whole industrial chain of core products, strengthen the core advantages of integration, and provide efficient, high-quality and cost-effective products, services and solutions for domestic and foreign partners.

　　(B) API quality management and EHS system compliance advantages

　　The company always regards quality management as the most important lifeline, and has established a comprehensive and leading cGMP standard quality system with the concept of systematic and scientific cGMP for a long time. All staff practice the advanced quality concept, inherit the advanced quality culture, and always implement all aspects of the quality system with the principles of high requirements, high standards and high quality, and continue to carry out learning and training to provide strong support for product research and development, production and sales, and constantly meet the new standards and requirements of customers. Its subsidiaries have successfully passed the official GMP on-site review of FDA, EU, NMPA of China and PMDA of Japan and the supplier audit of several large multinational pharmaceutical companies for many times.

　　(3) Reasonable production layout and advantages of large-scale production

　　The company has been deeply involved in the raw material medicine industry for many years, focusing on standardizing the production management of high-standard raw materials in the market. It has four raw material medicine production bases (Zhejiang Menuohua, Anhui Menuohua, Xuancheng Menuohua and Liaoyuan Pharmaceutical), which are located in major pharmaceutical and chemical parks in Zhejiang and Anhui. The reaction kettle has complete specifications, covering production capacity ranging from 50L to 12500L. At the same time, through the continuous upgrading and transformation of the base, the facilities and equipment for the production capacity of the company’s raw materials are complete, with a DCS control system with full coverage and an EHS system with leading wastewater, waste gas and solid waste treatment capacity, covering many kinds of chemical reactions, including Grignard reaction, azide reaction, Friedel-Crafts reaction, hydrogenation reaction, cyanidation reaction and redox reaction. The company makes full use of the leading chemical synthesis ability and high-standard production capacity of APIs to give full play to the scale effect of APIs.

　　At present, the company has sufficient reserves of high-standard, modern and advanced production capacity. The total production capacity of the four API production bases is about 3,700 tons/year, and the production capacity of Minolta Tiankang is 1.5 billion tablets/year. With the continuous development of the company’s operation and production, the continuous promotion of strategic transformation, and the increasing number of high-quality customers, the company actively deployed capacity expansion, in which the "3 billion tablets (granules) export solid preparation construction project" of Minolta was completed during the reporting period and is ready for trial production; The main body of the civil works in the first phase of Anhui Meinuohua’s "Technical Transformation Project with an annual output of 400 tons of APIs" has been completely completed, and the installation of workshop equipment has been basically completed, and some workshops are ready for trial production; The main body of the first phase project of "520 tons of pharmaceutical raw materials per year" in Zhejiang Meinuohua has been completed, and some workshops have completed electromechanical installation. In addition, the second phase expansion project of Xuancheng Meinuohua has been started.

　　(D) Rich international customer resources and diversified strategic cooperation modes.

　　The company has been deeply involved in overseas markets for many years. Since its inception, it has accumulated rich international high-quality customer resources and established long-term and deep and stable cooperative relations with many internationally renowned pharmaceutical companies. Among them, the company and KRKA have sublimated from strategic cooperation to strategic binding in the long-term win-win cooperation, and formed diversified cooperation modes such as joint research and development, joint declaration and joint imitation, which not only maintained long-term and stable cooperative relations in the fields of pharmaceutical intermediates and raw materials, but also expanded in-depth cooperation in the field of preparations.

　　The company adheres to the market development concept of "exploring new customers and deeply cultivating old customers", keeps up with the development pace of customers, keenly understands the market development trend and responds to customer needs quickly. With the release of the company’s production capacity and business expansion, the company’s brand influence and international popularity have been further enhanced, and the product market share has continued to rise.

　　(E) Advantages of high-end R&D technology platform

　　Adhering to the international R&D concept and combining scientific and rigorous quality research, the company has established an efficient R&D management system. The company currently has three R&D centers, including Zhejiang Menuohua Pharmaceutical Research Institute, Pharmaceutical Innovation Research Institute and Hangzhou Xinnuohua Pharmaceutical, with a total experimental site of more than 13,000 square meters. After years of development, the company has reserved talents through self-cultivation and external introduction, brought into full play the role of European experts, Indian experts and scientific research forces in universities, and cooperated with postdoctoral workstations and foreign expert workstations to successfully build a core talent team with outstanding technology, efficient management and high loyalty. As of June 30, 2022, the company has 376 R&D personnel of APIs and 139 R&D personnel of preparations, and the number of R&D personnel has increased by 13% compared with last year. It has rich experience in drug synthesis and preparation process development, quality research and strong technical level of process amplification. Continuous R&D innovation is one of the important factors for the company to maintain its competitive advantage and achieve rapid growth. The company will continue to increase investment in R&D and build its core technological advantages.

　　The company’s innovative ability of API R&D is outstanding, among which the API R&D Center has established a perfect R&D quality system and project management process to ensure the scientificity, authenticity, integrity and traceability of R&D projects. The R&D center can carry out various multi-step complex organic synthesis reactions, including hydrogenation (conventional high-pressure hydrogenation and asymmetric hydrogenation), various N- alkylation reactions, cyanidation reactions, azide reactions, chiral synthesis and resolution, redox reactions (reactions involving hydrogen peroxide, TEMPO, DIBAL-H, NaBH4, etc.), biological enzyme catalytic reactions, crystallization processes with special particle size or physical properties, etc. The center is equipped with advanced R&D equipment and technology.

　　In terms of process safety research, the company set up a special safety laboratory, trained a special reaction safety risk assessment team, and equipped with the latest high-precision instruments and equipment such as RC1max, ARC, TGA and DSC. The safety laboratory passed CNAS certification, which further provided safety guarantee for the company’s process safety and could also provide reaction safety risk assessment services for other enterprises.

　　In the aspect of chemical process amplification, aiming at the "three-pass and one-reverse" of chemical production, a process amplification department based on process and engineering experts was established, and a special process amplification research laboratory was set up, equipped with laboratory research equipment to simulate chemical production, and each process parameter was simulated and studied, and a systematic research and evaluation report on process parameters was put forward, thus avoiding various defects in the process of process amplification and ensuring the success rate of process amplification.

　　In quality research, the company’s quality research ability is excellent. The company has experienced quality researchers, equipped with several semi-preparative chromatographs, high-resolution triple quadrupole LC-MS and GC-MS, and can carry out evaluation and research on all kinds of impurities, including evaluation of genotoxic impurities and nitrosamine impurities, verification and detection of method development, separation and structure identification of unknown impurities, etc.

　　The company attaches great importance to the study of physical properties of APIs, and has set up special crystal research laboratories and particle size research laboratories. The company is not only equipped with different types of crushing research equipment, but also equipped with precise analysis equipment such as Brooke powder diffractometer, which can carry out crystal development, detection, stability research and particle size research.

　　GMP management is implemented in the company’s quality research work, which can provide a complete set of analytical method development, verification, sample testing and other services for domestic and foreign research units.

　　The Institute of Medical Innovation is a medical innovation platform integrating applied technology research and development, public technology service, introduction of high-level talents and incubation of high-end projects. It conducts research and development and pilot tests of various new technologies and new products around drugs and new materials, incubates entrepreneurial projects in related fields, and builds industrial clusters of drugs and new materials. The company has established a professional team with complete functions such as process development, quality analysis, clinical medicine, international and domestic registration, project management, technology transfer, etc., equipped with advanced equipment and instruments for preparation research and development at home and abroad; At the same time, a key technology platform for the development of pharmaceutical preparations has been established, and through this key technology platform, the industrialization of the company’s independent research and development preparation projects and the incubation of high-end projects have been realized, and public technical services have been provided to external pharmaceutical enterprises.

　　The company established the CDMO business unit, which is dedicated to the development of CDMO business and helps the company to transform and upgrade its strategy. Through the strategy of "Novartis+"and the extension Development, the company brings the development of D-end.

　　In order to enrich product reserves and cultivate long-term competitiveness, the company has always adhered to independent research and development innovation and continuously increased R&D investment. During the reporting period, 10 patents were declared and 26 patents were granted (including 3 inventions and 23 utility models). By the end of the reporting period, the company had authorized 163 patents (including 70 inventions and 93 utility models).

　　(6) Excellent management team and talent echelon

　　The company has established a leading pharmaceutical service platform in the world, with an international team of more than 2,700 people with rich experience in the industry. According to the characteristics of the international pharmaceutical market, the company actively introduced all kinds of medical professionals at home and abroad, and established professional teams in drug research and development, quality, pharmaceutical administration registration, process optimization, market development and intellectual property management that meet the international pharmaceutical industry standards. During the reporting period, in order to attract, retain and motivate outstanding talents and fully mobilize the enthusiasm of managers, core technicians and business backbones at all levels of the company, the company implemented the "2021 Stock Option and Restricted Stock Incentive Plan" and completed the first grant. The incentive covers key company management talents and core technical talents, so that the interests of shareholders, the company and the personal interests of the core team can be combined to jointly promote the long-term development of the company.